2-oxo-9-thia-3,12-diaza-tricyclo[8.2.1.0(3,7)]tridecane-12-benzyloxycarbonyl-4-carboxylic acid methyl ester

Base Information

Chemical Name:2-oxo-9-thia-3,12-diaza-tricyclo[8.2.1.0(3,7)]tridecane-12-benzyloxycarbonyl-4-carboxylic acid methyl ester
CAS No.:376585-21-6
Molecular Formula:C₂₀H₂₄N₂O₅S
Molecular Weight:404.487
Hs Code.:

Synonyms:2-oxo-9-thia-3,12-diaza-tricyclo[8.2.1.0(3,7)]tridecane-12-benzyloxycarbonyl-4-carboxylic acid methyl ester

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Chemical Property of 2-oxo-9-thia-3,12-diaza-tricyclo[8.2.1.0(3,7)]tridecane-12-benzyloxycarbonyl-4-carboxylic acid methyl ester

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Technology Process of 2-oxo-9-thia-3,12-diaza-tricyclo[8.2.1.0(3,7)]tridecane-12-benzyloxycarbonyl-4-carboxylic acid methyl ester

There total 9 articles about 2-oxo-9-thia-3,12-diaza-tricyclo[8.2.1.0(3,7)]tridecane-12-benzyloxycarbonyl-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 376585-20-5
5-[1-benzyloxycarbonyl-4-(toluene-4-sulfonyloxy)-pyrrolidine-2-carbonyl]-mercaptomethyl-pyrrolidine-2-carboxylic acid methyl ester

: 376585-21-6
2-oxo-9-thia-3,12-diaza-tricyclo[8.2.1.0(3,7)]tridecane-12-benzyloxycarbonyl-4-carboxylic acid methyl ester

Guidance literature:: With potassium methanolate; In methanol; acetonitrile; for 1h; Heating;
DOI:10.1021/ja010812a

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 376585-21-6
2-oxo-9-thia-3,12-diaza-tricyclo[8.2.1.0(3,7)]tridecane-12-benzyloxycarbonyl-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / sodium bicarbonate / H₂O; dioxane / 23 h / 0 - 20 °C

2.1: 63 percent / pyridine / 22 h / 4 °C

3.1: 93 percent / aq. NaOH / methanol / 15 h / 0 - 20 °C

4.1: 1,1-carbonyldiimidazole / acetonitrile / 1 h / 0 °C

4.2: 100 percent / acetonitrile / 16 h / 0 - 20 °C

5.1: trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

6.1: 7.99 g / N,N-diisopropylethylamine / toluene / 3 h / 60 °C

7.1: 93 percent / KOMe / acetonitrile; methanol / 1 h / Heating

With sodium hydroxide; potassium methanolate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In 1,4-dioxane; pyridine; methanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/ja010812a

Reference yield:

: 5-[1-benzyloxycarbonyl-4-(toluene-4-sulfonyloxy)-pyrrolidine-2-carbonyl]-mercaptomethyl-pyrrolidine-2-carboxylic acid methyl ester

: 376585-21-6
2-oxo-9-thia-3,12-diaza-tricyclo[8.2.1.0(3,7)]tridecane-12-benzyloxycarbonyl-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 7.99 g / N,N-diisopropylethylamine / toluene / 3 h / 60 °C

2: 93 percent / KOMe / acetonitrile; methanol / 1 h / Heating

With potassium methanolate; N-ethyl-N,N-diisopropylamine; In methanol; toluene; acetonitrile;
DOI:10.1021/ja010812a