1,3-dimethyl-3-phenethylindolin-2-one

Base Information

• Chemical Name: 1,3-dimethyl-3-phenethylindolin-2-one
• CAS No.: 1491270-74-6
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265.355
• Mol file: 1491270-74-6.mol

Synonyms:1,3-dimethyl-3-phenethylindolin-2-one

Chemical Property of 1,3-dimethyl-3-phenethylindolin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-dimethyl-3-phenethylindolin-2-one

There total 22 articles about 1,3-dimethyl-3-phenethylindolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-methyl-N-phenylmethacrylamide (15796-89-1) + toluene (108-88-3,15644-74-3,16713-13-6) → 1,3-dimethyl-3-phenethylindolin-2-one (1491270-74-6)

Guidance literature:

With copper(I) oxide; tert-Butyl peroxybenzoate; at 120 ℃; for 28h; Solvent; Reagent/catalyst; Concentration; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201302139

Reference yield: 92.0%

benzyldiisopropylamine (34636-09-4) + N-methyl-N-phenylmethacrylamide (15796-89-1) → 1,3-dimethyl-3-phenethylindolin-2-one (1491270-74-6)

Guidance literature:

With nickel(II) iodide; iodine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; at 150 ℃; for 24h; Reagent/catalyst; Temperature; Time; Mechanism; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201800543

Reference yield: 85.0%

N-methyl-N-phenylmethacrylamide (15796-89-1) + potassium benzyltrifluoroborate → 1,3-dimethyl-3-phenethylindolin-2-one (1491270-74-6)

Guidance literature:

With cobalt(II) acetate; sodium pivalate; In ethanol; at 20 ℃; for 12h; Electrochemical reaction; Inert atmosphere;

DOI:10.1039/c8ob02485e

upstream raw materials:

N-methyl-N-phenylmethacrylamide

toluene

⁽²⁾H₈-toluene

[D₁]-N-methyl-N-phenylmethacrylamide

Refernces

• 1、 Zhao, Yaping,Li, Zhenghua,Sharma, Upendra K.,Sharma, Nandini,Song, Gonghua,Van Der Eycken, Erik V.. "Copper-catalyzed alkylarylation of activated alkenes using isocyanides as the alkyl source: An efficient radical access to 3,3-dialkylated oxindoles". . p. 6395 - 6398. Retrieved 2016.
• 2、 -. "A antibacterial indole preparation method (by machine translation)". Paragraph 0053. . Retrieved 2019/02/06.
• 3、 Yu, Yue,Zheng, Peifeng,Wu, Yuanheng,Ye, Xiaoyi. "Electrochemical cobalt-catalyzed C-H or N-H oxidation: A facile route to synthesis of substituted oxindoles". supporting information. p. 8917 - 8921. Retrieved 2018/12/10.