cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine

Base Information

Chemical Name:cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine
CAS No.:78584-64-2
Molecular Formula:C₁₈H₂₉NO₄
Molecular Weight:323.433
Hs Code.:

Synonyms:cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine

Chemical Property:

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Technology Process of cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine

There total 8 articles about cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 917-54-4
methyllithium

: 78584-62-0,81835-84-9
cis-3-acetyl-1,3-dimethyl-3-(3,4,5-trimethoxyphenyl)pyrrolidine

: 78584-64-2
cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine

Guidance literature:: In tetrahydrofuran; diethyl ether; for 6h; Heating;

Reference yield:

: 1123-19-9,112607-28-0,112607-29-1
3-acetyl-3-methyl-dihydro-furan-2-one

: 78584-64-2
cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: 10percent HCl / Heating

2: 65 percent / dimethylformamide / 8 h / Heating

3: 86 percent / p-toluenesulfonic acid / benzene / 12 h / Heating

4: 1) hydrazine hydrate 2) 20percent NaOH / 1) ethanol, reflux, 2 h 2) water, 15 min

5: 92 percent / benzene

6: 45 percent / HCl / diethyl ether; CH₂Cl₂ / 1) 3 h, reflux; 2) 20percent HCl, 1 h, room temp.

7: 82 percent / potassium carbonate / acetone

8: 85 percent / diethyl ether; tetrahydrofuran / 6 h / Heating

With hydrogenchloride; sodium hydroxide; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; benzene;

Reference yield:

: 78584-55-1
5-amino-3-methyl-2-pentanone ethylene acetal

: 78584-64-2
cis-3-(2-hydroxy-2-propyl)-1,3-dimethyl-2-(3,4,5-trimethoxyphenyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / benzene

2: 45 percent / HCl / diethyl ether; CH₂Cl₂ / 1) 3 h, reflux; 2) 20percent HCl, 1 h, room temp.

3: 82 percent / potassium carbonate / acetone

4: 85 percent / diethyl ether; tetrahydrofuran / 6 h / Heating

With hydrogenchloride; potassium carbonate; In tetrahydrofuran; diethyl ether; dichloromethane; acetone; benzene;