methyl 3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate

Base Information

Chemical Name:methyl 3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate
CAS No.:597584-97-9
Molecular Formula:C₂₅H₃₂N₂O₂
Molecular Weight:392.541
Hs Code.:

Synonyms:methyl 3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate

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Chemical Property of methyl 3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate

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Technology Process of methyl 3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate

There total 7 articles about methyl 3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 17247-58-4
(Bromomethyl)cyclobutane

: 597584-88-8
methyl [4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]acetate

: 597584-97-9
methyl 3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate

Guidance literature:: methyl [4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]acetate; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 2h;

(Bromomethyl)cyclobutane; In tetrahydrofuran; toluene; at 20 ℃;
DOI:10.1021/jm0301078

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 597584-97-9
methyl 3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2.1: 90 percent / KOAc; Pd(Cl)2dppf / dimethylformamide / 3 h / 70 - 90 °C

3.1: 75 percent / aq. sodium carbonate; Pd(Cl₂)pddf / dimethylformamide / 2.5 h / 100 °C

4.1: KHMDS / tetrahydrofuran; toluene / 2 h / 0 - 20 °C

4.2: 6 percent / tetrahydrofuran; toluene / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Pd(Cl₂)pddf; potassium acetate; potassium hexamethylsilazane; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 3.1: Suzuki cross-coupling;
DOI:10.1021/jm0301078

Reference yield:

: 66698-28-0
1-(4-bromophenyl)piperazine

: 597584-97-9
methyl 3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 1 h / 20 °C

1.2: 71 percent / dimethylformamide / 1.25 h / -78 - 20 °C

2.1: 75 percent / aq. sodium carbonate; Pd(Cl₂)pddf / dimethylformamide / 2.5 h / 100 °C

3.1: KHMDS / tetrahydrofuran; toluene / 2 h / 0 - 20 °C

3.2: 6 percent / tetrahydrofuran; toluene / 20 °C

With Pd(Cl₂)pddf; potassium hexamethylsilazane; sodium hydride; sodium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 2.1: Suzuki cross-coupling;
DOI:10.1021/jm0301078