(4,4-dimethyl-3,4-dihydrocarbostyril)-6-carboxylic acid (E)-4-[2-(hydroxycarbamoyl)vinyl]benzylamide

Base Information

Chemical Name:(4,4-dimethyl-3,4-dihydrocarbostyril)-6-carboxylic acid (E)-4-[2-(hydroxycarbamoyl)vinyl]benzylamide
CAS No.:1616590-16-9
Molecular Formula:C₂₂H₂₃N₃O₄
Molecular Weight:393.442
Hs Code.:

Synonyms:(4,4-dimethyl-3,4-dihydrocarbostyril)-6-carboxylic acid (E)-4-[2-(hydroxycarbamoyl)vinyl]benzylamide

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Chemical Property of (4,4-dimethyl-3,4-dihydrocarbostyril)-6-carboxylic acid (E)-4-[2-(hydroxycarbamoyl)vinyl]benzylamide

Chemical Property:

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Technology Process of (4,4-dimethyl-3,4-dihydrocarbostyril)-6-carboxylic acid (E)-4-[2-(hydroxycarbamoyl)vinyl]benzylamide

There total 7 articles about (4,4-dimethyl-3,4-dihydrocarbostyril)-6-carboxylic acid (E)-4-[2-(hydroxycarbamoyl)vinyl]benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616590-38-5
(E)-3-[4-(4,4-dimethyl-3,4-dihydrocarbostyril-6-carbonyl)aminomethylphenyl]acrylic acid ethyl ester

: 1616590-16-9
(4,4-dimethyl-3,4-dihydrocarbostyril)-6-carboxylic acid (E)-4-[2-(hydroxycarbamoyl)vinyl]benzylamide

Guidance literature:: (E)-3-[4-(4,4-dimethyl-3,4-dihydrocarbostyril-6-carbonyl)aminomethylphenyl]acrylic acid ethyl ester; With hydroxylamine; In methanol; water; at 0 ℃; for 0.0666667h;

With sodium methylate; In methanol; water; at 0 ℃; for 1h;
DOI:10.1016/j.bmc.2014.05.001

Reference yield:

: 383665-96-1
(E)-3-[4-(tert-butoxycarbonylaminomethyl)phenyl]acrylic acid ethyl ester

: 1616590-16-9
(4,4-dimethyl-3,4-dihydrocarbostyril)-6-carboxylic acid (E)-4-[2-(hydroxycarbamoyl)vinyl]benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

3.1: hydroxylamine / methanol; water / 0.07 h / 0 °C

3.2: 1 h / 0 °C

With hydroxylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.05.001

Reference yield:

: 153171-22-3
2-(4-bromobenzyl)-1H-isoindole-1,3(2H)-dione

: 1616590-16-9
(4,4-dimethyl-3,4-dihydrocarbostyril)-6-carboxylic acid (E)-4-[2-(hydroxycarbamoyl)vinyl]benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / methanol / 1 h / Reflux

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: palladium diacetate; propiononitrile; tris-(o-tolyl)phosphine; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6.5 h / 90 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

6.1: hydroxylamine / methanol; water / 0.07 h / 0 °C

6.2: 1 h / 0 °C

With hydroxylamine; palladium diacetate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; propiononitrile; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.05.001