N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide

Base Information

Chemical Name:N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide
CAS No.:937276-27-2
Molecular Formula:C₁₅H₂₀N₂O₅
Molecular Weight:308.334
Hs Code.:

N<sup>α</sup>-(benzyloxycarbonyl)-N<sup>β</sup>-(tert-butoxycarbonyl)-N<sup>β</sup>-(formylmethyl)hydrazide

Synonyms:N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide

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Chemical Property of N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide

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Technology Process of N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide

There total 3 articles about N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 937276-26-1
N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

: 937276-27-2
N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide

Guidance literature:: With Dess-Martin periodane; In dichloromethane; water; at 20 ℃; for 1h;
DOI:10.1016/j.tet.2017.03.052

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 937276-27-2
N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / ethanol / 26 h / 20 °C

2.1: 93 percent / NaOH / CH₂Cl₂; H₂O / 20 h / 20 °C

3.1: Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.83 h / 20 °C

3.2: methyl tert-butyl ether; NaHCO₃; Na₂S₂O₃ / CH₂Cl₂; H₂O / 0.42 h / 20 °C

With sodium hydroxide; Dess-Martin periodane; In ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2007.02.102

Reference yield:

: 114897-60-8
N^β-(tert-butoxycarbonyl)-N^β-(2-hydroxyethyl)hydrazide

: 937276-27-2
N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-(formylmethyl)hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / NaOH / CH₂Cl₂; H₂O / 20 h / 20 °C

2.1: Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.83 h / 20 °C

2.2: methyl tert-butyl ether; NaHCO₃; Na₂S₂O₃ / CH₂Cl₂; H₂O / 0.42 h / 20 °C

With sodium hydroxide; Dess-Martin periodane; In dichloromethane; water;
DOI:10.1016/j.tet.2007.02.102