3-CHLOROPHENYLPHOSPHONIC ACID

Base Information

• Chemical Name: 3-CHLOROPHENYLPHOSPHONIC ACID
• CAS No.: 5431-34-5
• Molecular Formula: C6H6 Cl O3 P
• Molecular Weight: 192.539
• Mol file: 5431-34-5.mol

Synonyms:Phosphonicacid, (3-chlorophenyl)- (9CI); Phosphonic acid, (m-chlorophenyl)- (6CI,7CI);(3-Chlorophenyl)phosphonic acid; (m-Chlorophenyl)phosphonic acid; NSC 13559

Chemical Property of 3-CHLOROPHENYLPHOSPHONIC ACID

Chemical Property:

• Vapor Pressure: 6.09E-07mmHg at 25°C
• Boiling Point: 394.8°Cat760mmHg
• PKA: pK1: 1.55;pK2: 6.65 (25°C)
• Flash Point: 192.6°C
• Density: 1.57g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLOROPHENYLPHOSPHONIC ACID

There total 4 articles about 3-CHLOROPHENYLPHOSPHONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylphosphonate (1571-33-1) → 3-chloro-phenyl phosphonic acid (5431-34-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NO₂/HNO₃, (ii) aq. NaOH, Na₂S

2: (i) NaNO₂, aq. HCl, (ii) CuCl, aq. HCl

Reference yield:

3-iodochlorobenzene (625-99-0) → 3-chloro-phenyl phosphonic acid (5431-34-5)

Guidance literature:

3-iodochlorobenzene; With 1,3-bis-(diphenylphosphino)propane; hypophosphorous acid; triethylamine; palladium diacetate; In N,N-dimethyl-formamide; at 85 ℃; for 15h;

With oxygen; In N,N-dimethyl-formamide; at 110 ℃; for 22h; Further stages.;

DOI:10.1016/j.tetlet.2007.06.090

Reference yield:

→ 3-chloro-phenyl phosphonic acid (5431-34-5)

Guidance literature:

With copper(I) bromide; phosphorus trichloride;

DOI:10.1021/ja01156a049

upstream raw materials:

m-aminophenylphosphonic acid

3-iodochlorobenzene

phenylphosphonate

Refernces

• 1、 Bravo-Altamirano, Karla,Montchamp, Jean-Luc. "A novel approach to phosphonic acids from hypophosphorous acid". . p. 5755 - 5759. Retrieved 2008/02/09.