1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylic acid

Base Information

Chemical Name:1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylic acid
CAS No.:98772-11-3
Molecular Formula:C₁₂H₈F₃N₃O₃
Molecular Weight:299.209
Hs Code.:

Synonyms:1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylic acid

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Chemical Property of 1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylic acid

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Technology Process of 1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylic acid

There total 3 articles about 1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 98771-87-0
ethyl 1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylate

: 98772-11-3
1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 80 ℃; for 2h;
DOI:10.1248/cpb.37.1780

Reference yield:

: 53554-29-3
ethyl 3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carboxylate

: 98772-11-3
1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 2 h / 130 °C

2: 68 percent / 4percent aq. NaOH / methanol / 2 h / 80 °C

With sodium hydroxide; In methanol;
DOI:10.1248/cpb.37.1780

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 98772-11-3
1,6-dihydro-6-oxo-2-(3-trifluoromethylanilino)-5-pyrimidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 2 h / 130 °C

2: 68 percent / 4percent aq. NaOH / methanol / 2 h / 80 °C

With sodium hydroxide; In methanol;
DOI:10.1248/cpb.37.1780