N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Chemical Name:N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide
CAS No.:176747-34-5
Molecular Formula:C₄₃H₄₇N₃O₈S₂
Molecular Weight:797.993
Hs Code.:

N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Synonyms:N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Chemical Property of N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

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Technology Process of N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

There total 8 articles about N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 176747-33-4
N-{1-[(2R,3R,4R,5R)-3-(2-tert-Butyldisulfanyl-ethoxy)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

: 176747-34-5
N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: With pyridine; dmap; In N,N-dimethyl-formamide; for 6h; Ambient temperature;
DOI:10.1021/ja960091t

Reference yield:

: N-[1-((2R,3R,3aR,9aR)-3-Allyloxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide

: 176747-34-5
N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / N-methylmorpholine N-oxide, aq. OsO₄ / acetone / 2.5 h / Ambient temperature

2: 97 percent / aq. NaIO₄ / dioxane / 4.5 h / Ambient temperature

3: 93 percent / NaBH₄ / methanol / 90 h / Ambient temperature

4: 92 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

5: 76 percent / Et₃N / dimethylformamide / Ambient temperature

6: 100 percent / 48percent aq. HF / acetonitrile / 7 h / Ambient temperature

7: 74 percent / LiOH*H₂O / methanol; tetrahydrofuran / 0.75 h / 0 °C

8: 77 percent / DMAP, pyridine / dimethylformamide / 6 h / Ambient temperature

With pyridine; dmap; lithium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; hydrogen fluoride; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/ja960091t

Reference yield:

: 176747-32-3
Thiobenzoic acid S-{2-[(2R,3R,4R,5R)-2-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yloxy]-ethyl} ester

: 176747-34-5
N-{1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(2-tert-butyldisulfanyl-ethoxy)-4-hydroxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / LiOH*H₂O / methanol; tetrahydrofuran / 0.75 h / 0 °C

2: 77 percent / DMAP, pyridine / dimethylformamide / 6 h / Ambient temperature

With pyridine; dmap; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja960091t