(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(6-fluoropyridin-3-yl)urea

Base Information

Chemical Name:(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(6-fluoropyridin-3-yl)urea
CAS No.:1323276-38-5
Molecular Formula:C₁₈H₂₀FN₅O₃
Molecular Weight:373.387
Hs Code.:

Synonyms:(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(6-fluoropyridin-3-yl)urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(6-fluoropyridin-3-yl)urea

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Technology Process of (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(6-fluoropyridin-3-yl)urea

There total 3 articles about (S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(6-fluoropyridin-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1037621-09-2
C₈H₁₁FN₄O

: 93744-18-4
(S)-(+)-3-(2-cyanophenoxy)-1,2-epoxypropane

: 1323276-38-5
(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(6-fluoropyridin-3-yl)urea

Guidance literature:: With diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate; In acetonitrile; at 74 - 85 ℃;
DOI:10.1021/ml1002458

Reference yield:

: tert-butyl 2-(3-(6-fluoropyridine-3-yl)ureido)ethylcarbamate

: 1323276-38-5
(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(6-fluoropyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C

2: diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate / acetonitrile / 74 - 85 °C

With hydrogenchloride; diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate; In 1,4-dioxane; acetonitrile;
DOI:10.1021/ml1002458

Reference yield:

: 1827-27-6
2-fluoro-5-aminopyridine

: 1323276-38-5
(S)-1-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-3-(6-fluoropyridin-3-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

3: diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate / acetonitrile / 74 - 85 °C

With hydrogenchloride; diethyl methoxy borane; N-ethyl-N,N-diisopropylamine; ytterbium(III) triflate; In tetrahydrofuran; 1,4-dioxane; acetonitrile;
DOI:10.1021/ml1002458