N₁-phenyl-2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1,3,5-trimethyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide

Base Information

• Chemical Name: N₁-phenyl-2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1,3,5-trimethyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide
• CAS No.: 1027008-42-9
• Molecular Formula: C₂₀H₂₈N₄O₄
• Molecular Weight: 388.467

Synonyms:N₁-phenyl-2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1,3,5-trimethyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide

Chemical Property of N₁-phenyl-2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1,3,5-trimethyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide

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Technology Process of N₁-phenyl-2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1,3,5-trimethyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide

There total 1 articles about N₁-phenyl-2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1,3,5-trimethyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-methoxy-2-methyl-3-trimethylsilyloxy-1,3-pentadiene + 4-dimethylaminocarbonyl-3-methyl-1-phenylaminocarbonyl-1,2-diaza-1,3-butadiene (1027008-08-7) → N1-phenyl-2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1,3,5-trimethyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide (1027008-42-9)

Guidance literature:

1-methoxy-2-methyl-3-trimethylsilyloxy-1,3-pentadiene; 4-dimethylaminocarbonyl-3-methyl-1-phenylaminocarbonyl-1,2-diaza-1,3-butadiene; With zinc(II) chloride; In dichloromethane; at 20 ℃; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; optical yield given as %de; diastereoselective reaction;

DOI:10.1021/ol800557h

Reference yield: 61.0%

N1-phenyl-2-{(5E)-2-[(dimethylamino)carbonyl]-6-methoxy-1,3,5-trimethyl-4-oxo-5-hexenylidene}-1-hydrazinecarboxamide (1027008-42-9) → N1-phenyl-3-{2-[(dimethylamino)carbonyl]-1-methyl-3-oxobutyl}-4-methyl-1H-1-pyrazolecarboxamide (1027008-76-9)

Guidance literature:

With Amberlyst 15; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/ol800557h

upstream raw materials:

4-dimethylaminocarbonyl-3-methyl-1-phenylaminocarbonyl-1,2-diaza-1,3-butadiene

Downstream raw materials:

N₁-phenyl-3-{2-[(dimethylamino)carbonyl]-1-methyl-3-oxobutyl}-4-methyl-1H-1-pyrazolecarboxamide

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