4-[4-(6-fluoro-1H-benzimidazol-2-yl)-3-methylindazol-1-yl]-2-(2-hydroxy-2-methyl-propylamino)benzamide

Base Information

Chemical Name:4-[4-(6-fluoro-1H-benzimidazol-2-yl)-3-methylindazol-1-yl]-2-(2-hydroxy-2-methyl-propylamino)benzamide
CAS No.:1246306-94-4
Molecular Formula:C₂₆H₂₅FN₆O₂
Molecular Weight:472.522
Hs Code.:

Synonyms:4-[4-(6-fluoro-1H-benzimidazol-2-yl)-3-methylindazol-1-yl]-2-(2-hydroxy-2-methyl-propylamino)benzamide

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Chemical Property of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-3-methylindazol-1-yl]-2-(2-hydroxy-2-methyl-propylamino)benzamide

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Technology Process of 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-3-methylindazol-1-yl]-2-(2-hydroxy-2-methyl-propylamino)benzamide

There total 9 articles about 4-[4-(6-fluoro-1H-benzimidazol-2-yl)-3-methylindazol-1-yl]-2-(2-hydroxy-2-methyl-propylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246306-98-8
4-[4-(6-fluoro-1H-benzimidazol-2-yl)-3-methylindazol-1-yl]-2-(2-hydroxy-2-methylpropylamino)benzonitrile

: 1246306-94-4
4-[4-(6-fluoro-1H-benzimidazol-2-yl)-3-methylindazol-1-yl]-2-(2-hydroxy-2-methyl-propylamino)benzamide

Guidance literature:: With water; dihydrogen peroxide; sodium hydroxide; In ethanol; dimethyl sulfoxide; at 20 ℃; for 0.75h;

Reference yield:

: 848678-69-3
trifluoromethanesulphonic acid 3-methyl-1H-indazol-4-yl ester

: 1246306-94-4
4-[4-(6-fluoro-1H-benzimidazol-2-yl)-3-methylindazol-1-yl]-2-(2-hydroxy-2-methyl-propylamino)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 16 h / 50 °C / 1500.15 Torr / Autoclave

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C / Inert atmosphere

3: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3.5 h / 90 °C / Inert atmosphere

4: water; sodium hydroxide / 1,4-dioxane; methanol / 4 h / 20 °C / Inert atmosphere

5: O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6: acetic acid / 0.75 h / 115 °C / Inert atmosphere; Microwave irradiation

7: water; dihydrogen peroxide; sodium hydroxide / ethanol; dimethyl sulfoxide / 0.75 h / 20 °C

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; water; dihydrogen peroxide; sodium hydride; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 149071-05-6
3-methyl-4-hydroxyindazole

: 1246306-94-4
4-[4-(6-fluoro-1H-benzimidazol-2-yl)-3-methylindazol-1-yl]-2-(2-hydroxy-2-methyl-propylamino)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere

2: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 16 h / 50 °C / 1500.15 Torr / Autoclave

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 20 °C / Inert atmosphere

4: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3.5 h / 90 °C / Inert atmosphere

5: water; sodium hydroxide / 1,4-dioxane; methanol / 4 h / 20 °C / Inert atmosphere

6: O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

7: acetic acid / 0.75 h / 115 °C / Inert atmosphere; Microwave irradiation

8: water; dihydrogen peroxide; sodium hydroxide / ethanol; dimethyl sulfoxide / 0.75 h / 20 °C

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; water; dihydrogen peroxide; sodium hydride; caesium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;