3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid tert-butyl ester

Base Information

• Chemical Name: 3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid tert-butyl ester
• CAS No.: 1025889-20-6
• Molecular Formula: C₄₁H₃₉NO₇
• Molecular Weight: 657.763
• Mol file: 1025889-20-6.mol

Synonyms:3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid tert-butyl ester

Chemical Property of 3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid tert-butyl ester

There total 2 articles about 3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-Bis-benzyloxy-4-chlorocarbonyl-benzoic acid tert-butyl ester (158980-58-6) + benzyl N-phenylglycinate toluenesulfonic acid salt → 3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid tert-butyl ester (1025889-20-6)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 96h;

DOI:10.1021/jm020018f

Reference yield:

2,6-bis(benzyloxy)-4-<(1,1-dimethylethoxy)carbonyl>benzoic acid (158980-56-4) → 3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid tert-butyl ester (1025889-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂; dimethylformamide / 3 h / 20 °C

2: iPr₂NEt; DMAP / CH₂Cl₂ / 96 h / 20 °C

With dmap; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm020018f

Reference yield:

3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid tert-butyl ester (1025889-20-6) → 3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid (440105-22-6)

Guidance literature:

With formic acid; at 20 ℃; for 3h;

DOI:10.1021/jm020018f

upstream raw materials:

3,5-Bis-benzyloxy-4-chlorocarbonyl-benzoic acid tert-butyl ester

2,6-bis(benzyloxy)-4-<(1,1-dimethylethoxy)carbonyl>benzoic acid

Downstream raw materials:

3,5-bis-benzyloxy-N-benzyloxycarbonylmethyl-N-phenyl-terephthalamic acid