(3-Benzyloxy-2-fluoro-1,1,2-trimethyl-propoxy)-tert-butyl-dimethyl-silane

Base Information

Chemical Name:(3-Benzyloxy-2-fluoro-1,1,2-trimethyl-propoxy)-tert-butyl-dimethyl-silane
CAS No.:199191-08-7
Molecular Formula:C₁₉H₃₃FO₂Si
Molecular Weight:340.554
Hs Code.:

Synonyms:(3-Benzyloxy-2-fluoro-1,1,2-trimethyl-propoxy)-tert-butyl-dimethyl-silane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3-Benzyloxy-2-fluoro-1,1,2-trimethyl-propoxy)-tert-butyl-dimethyl-silane

Chemical Property:

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Technology Process of (3-Benzyloxy-2-fluoro-1,1,2-trimethyl-propoxy)-tert-butyl-dimethyl-silane

There total 7 articles about (3-Benzyloxy-2-fluoro-1,1,2-trimethyl-propoxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 199191-06-5
4-benzyloxy-3-fluoro-2,3-dimethylbutan-2-ol

: 199191-08-7
(3-Benzyloxy-2-fluoro-1,1,2-trimethyl-propoxy)-tert-butyl-dimethyl-silane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1039/a702810e

Reference yield:

: 5658-46-8
((2-methylallyloxy)methyl)benzene

: 199191-08-7
(3-Benzyloxy-2-fluoro-1,1,2-trimethyl-propoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / m-CPBA, NaHCO₃ / CH₂Cl₂ / 2 h / Ambient temperature

2: 69 percent / SiF₄, (i-Pr)2NEt, H₂O / diethyl ether / 2 h / 0 °C

3: Dess-Martin periodinane / CH₂Cl₂ / 2 h / Ambient temperature

4: aq. NaClO₂, 2-methylbut-2-ene, phosphate buffer / 2-methyl-propan-2-ol / 2 h / Ambient temperature

5: tetrahydrofuran / 3 h / Ambient temperature

6: 87 percent / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

7: 90 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 2 h / 0 °C

With 2,6-dimethylpyridine; sodium chlorite; phosphate buffer; 2-methyl-but-2-ene; water; silicon tetrafluoride; sodium hydrogencarbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1039/a702810e

Reference yield:

: 117581-75-6
3-Benzyloxy-2-fluoro-2-methyl-propionaldehyde

: 199191-08-7
(3-Benzyloxy-2-fluoro-1,1,2-trimethyl-propoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaClO₂, 2-methylbut-2-ene, phosphate buffer / 2-methyl-propan-2-ol / 2 h / Ambient temperature

2: tetrahydrofuran / 3 h / Ambient temperature

3: 87 percent / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

4: 90 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 2 h / 0 °C

With 2,6-dimethylpyridine; sodium chlorite; phosphate buffer; 2-methyl-but-2-ene; In tetrahydrofuran; diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1039/a702810e