N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-2-(quinolin-4-ylamino)benzamide

Base Information

Chemical Name:N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-2-(quinolin-4-ylamino)benzamide
CAS No.:1535187-93-9
Molecular Formula:C₂₇H₂₃N₇O
Molecular Weight:461.526
Hs Code.:

Synonyms:N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-2-(quinolin-4-ylamino)benzamide

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Chemical Property of N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-2-(quinolin-4-ylamino)benzamide

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Technology Process of N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-2-(quinolin-4-ylamino)benzamide

There total 7 articles about N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-2-(quinolin-4-ylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 20719-43-1
N⁴-(4-aminophenyl)-6-methyl-2,4-diamino-pyrimidine

: 52180-97-9
2-quinolin-4-ylamino-benzoic acid

: 1535187-93-9
N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-2-(quinolin-4-ylamino)benzamide

Guidance literature:: 2-quinolin-4-ylamino-benzoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

N⁴-(4-aminophenyl)-6-methyl-2,4-diamino-pyrimidine; In N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1021/jm4012627

Reference yield:

: 1111618-69-9
ethyl 2-(quinolin-4-ylamino)benzoate

: 1535187-93-9
N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-2-(quinolin-4-ylamino)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide / ethanol / 20 °C

2.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm4012627

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 1535187-93-9
N-(4-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-2-(quinolin-4-ylamino)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol / 2 h / 80 °C

2.1: hydrogenchloride; stannous chloride dihydrate / ethanol; water / 1 h / 0 - 80 °C

3.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With hydrogenchloride; stannous chloride dihydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4012627