20(17->18)-abeo-3-O-(triethylsilyl)-1α-[(triethylsilyl)oxy]-25-hydroxy-22,23-dihomo-21-norvitamin D3

Base Information

Chemical Name:20(17->18)-abeo-3-O-(triethylsilyl)-1α-[(triethylsilyl)oxy]-25-hydroxy-22,23-dihomo-21-norvitamin D3
CAS No.:1309604-75-8
Molecular Formula:C₄₀H₇₄O₃Si₂
Molecular Weight:659.197
Hs Code.:

Synonyms:20(17->18)-abeo-3-O-(triethylsilyl)-1α-[(triethylsilyl)oxy]-25-hydroxy-22,23-dihomo-21-norvitamin D3

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Chemical Property of 20(17->18)-abeo-3-O-(triethylsilyl)-1α-[(triethylsilyl)oxy]-25-hydroxy-22,23-dihomo-21-norvitamin D3

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Technology Process of 20(17->18)-abeo-3-O-(triethylsilyl)-1α-[(triethylsilyl)oxy]-25-hydroxy-22,23-dihomo-21-norvitamin D3

There total 10 articles about 20(17->18)-abeo-3-O-(triethylsilyl)-1α-[(triethylsilyl)oxy]-25-hydroxy-22,23-dihomo-21-norvitamin D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: C₃₃H₅₁O₃PSi₂

: 733047-52-4
20(17->18)-abeo-de-A,B-25-hydroxy-22,23-dihomo-21-norcholestan-8-one

: 1309604-75-8
20(17->18)-abeo-3-O-(triethylsilyl)-1α-[(triethylsilyl)oxy]-25-hydroxy-22,23-dihomo-21-norvitamin D3

Guidance literature:: C₃₃H₅₁O₃PSi₂; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

20(17->18)-abeo-de-A,B-25-hydroxy-22,23-dihomo-21-norcholestan-8-one; In tetrahydrofuran; hexane; at -78 - -55 ℃; for 6h; Darkness;
DOI:10.1002/cmdc.201100021

Reference yield:

: C₂₉H₄₈O₄SSi

: 1309604-75-8
20(17->18)-abeo-3-O-(triethylsilyl)-1α-[(triethylsilyl)oxy]-25-hydroxy-22,23-dihomo-21-norvitamin D3

Guidance literature:: Multi-step reaction with 9 steps

1.1: dimethyl sulfoxide / 2 h / 90 °C

2.1: diisobutylaluminium hydride / dichloromethane / 2 h / -10 °C

3.1: diethyl ether / 1 h / -78 °C

4.1: PDC / dichloromethane / 24 h / 20 °C

5.1: diethyl ether / 2 h / -78 °C

6.1: pyridine; hydrogen fluoride; triethylamine / dichloromethane; acetonitrile / 48 h / 20 °C

7.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C

8.1: PDC / dichloromethane / 24 h / 20 °C

9.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

9.2: 6 h / -78 - -55 °C / Darkness

With pyridine; n-butyllithium; 5%-palladium/activated carbon; PDC; hydrogen fluoride; hydrogen; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; ethyl acetate; acetonitrile;
DOI:10.1002/cmdc.201100021

Reference yield:

: C₂₅H₄₈O₂Si

: 1309604-75-8
20(17->18)-abeo-3-O-(triethylsilyl)-1α-[(triethylsilyl)oxy]-25-hydroxy-22,23-dihomo-21-norvitamin D3

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; hydrogen fluoride; triethylamine / dichloromethane; acetonitrile / 48 h / 20 °C

2.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 16 h / 20 °C

3.1: PDC / dichloromethane / 24 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

4.2: 6 h / -78 - -55 °C / Darkness

With pyridine; n-butyllithium; 5%-palladium/activated carbon; PDC; hydrogen fluoride; hydrogen; triethylamine; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1002/cmdc.201100021