5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

Base Information

• Chemical Name: 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan
• CAS No.: 676324-43-9
• Molecular Formula: C₂₆H₂₃ClN₂O₂
• Molecular Weight: 430.934
• Mol file: 676324-43-9.mol

Synonyms:5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

Chemical Property of 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

There total 3 articles about 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxy-17-methylpyrido[2',3':6,7]morphinan (676324-42-8) → 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan (676324-43-9)

Guidance literature:

5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxy-17-methylpyrido[2',3':6,7]morphinan; With Vinyl chloroformate; potassium carbonate; In 1,2-dichloro-ethane; for 36h; Heating;

With hydrogenchloride; In ethanol; for 2h; Heating;

DOI:10.1021/jm030311v

Reference yield:

2-(4-chlorophenyl)malondialdehyde → 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan (676324-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 55 percent / AcONH₄; AcOH / 18 h / Heating

2.1: K₂CO₃; vinyl chloroformate / 1,2-dichloro-ethane / 36 h / Heating

2.2: 53 percent / aq. HCl / ethanol / 2 h / Heating

With Vinyl chloroformate; ammonium acetate; potassium carbonate; acetic acid; In 1,2-dichloro-ethane;

DOI:10.1021/jm030311v

Reference yield:

Hydrocodone (125-29-1) → 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan (676324-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 55 percent / AcONH₄; AcOH / 18 h / Heating

2.1: K₂CO₃; vinyl chloroformate / 1,2-dichloro-ethane / 36 h / Heating

2.2: 53 percent / aq. HCl / ethanol / 2 h / Heating

With Vinyl chloroformate; ammonium acetate; potassium carbonate; acetic acid; In 1,2-dichloro-ethane;

DOI:10.1021/jm030311v

upstream raw materials:

5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxy-17-methylpyrido[2',3':6,7]morphinan

Hydrocodone

Downstream raw materials:

5'-(4-chlorophenyl)-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan