5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

Base Information

Chemical Name:5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan
CAS No.:676324-43-9
Molecular Formula:C₂₆H₂₃ClN₂O₂
Molecular Weight:430.934
Hs Code.:

Synonyms:5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

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Chemical Property of 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

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Technology Process of 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

There total 3 articles about 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 676324-42-8
5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxy-17-methylpyrido[2',3':6,7]morphinan

: 676324-43-9
5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

Guidance literature:: 5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxy-17-methylpyrido[2',3':6,7]morphinan; With Vinyl chloroformate; potassium carbonate; In 1,2-dichloro-ethane; for 36h; Heating;

With hydrogenchloride; In ethanol; for 2h; Heating;
DOI:10.1021/jm030311v

Reference yield:

: 2-(4-chlorophenyl)malondialdehyde

: 676324-43-9
5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

Guidance literature:: Multi-step reaction with 2 steps

1.1: 55 percent / AcONH₄; AcOH / 18 h / Heating

2.1: K₂CO₃; vinyl chloroformate / 1,2-dichloro-ethane / 36 h / Heating

2.2: 53 percent / aq. HCl / ethanol / 2 h / Heating

With Vinyl chloroformate; ammonium acetate; potassium carbonate; acetic acid; In 1,2-dichloro-ethane;
DOI:10.1021/jm030311v

Reference yield:

: 125-29-1
Hydrocodone

: 676324-43-9
5'-(4-chlorophenyl)-6,7-didehydro-4,5α-epoxy-3-methoxypyrido[2',3':6,7]morphinan

Guidance literature:: Multi-step reaction with 2 steps

1.1: 55 percent / AcONH₄; AcOH / 18 h / Heating

2.1: K₂CO₃; vinyl chloroformate / 1,2-dichloro-ethane / 36 h / Heating

2.2: 53 percent / aq. HCl / ethanol / 2 h / Heating

With Vinyl chloroformate; ammonium acetate; potassium carbonate; acetic acid; In 1,2-dichloro-ethane;
DOI:10.1021/jm030311v