4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Base Information

Chemical Name:4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate
CAS No.:1350759-43-1
Molecular Formula:C₂HF₃O₂*C₂₂H₁₉Cl₂F₃N₂O₄
Molecular Weight:617.329
Hs Code.:

Synonyms:4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

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Chemical Property of 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

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Technology Process of 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

There total 4 articles about 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350761-92-0
methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoate

: 76-05-1
trifluoroacetic acid

: 1350759-43-1
4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Guidance literature:: methyl 4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoate; With water; lithium hydroxide; In tetrahydrofuran; at 70 ℃; for 3h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1350760-79-0
1,3-dichloro-5-methyl-2-(trifluoromethoxy)benzene

: 1350759-43-1
4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / 20 - 80 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 55 °C

3: zinc; acetic acid / 0.17 h / 35 °C

4: water; lithium hydroxide / tetrahydrofuran / 3 h / 70 °C

With N-Bromosuccinimide; water; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1350762-39-8
C₂₃H₂₀BrCl₂F₃N₂O₄

: 1350759-43-1
4-{8-[3,5-dichloro-4-(trifluoromethoxy)benzyl]-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl}benzoic acid trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; acetic acid / 0.17 h / 35 °C

2: water; lithium hydroxide / tetrahydrofuran / 3 h / 70 °C

With water; acetic acid; lithium hydroxide; zinc; In tetrahydrofuran;