dibenzyl N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-α-aspartate

Base Information

Chemical Name:dibenzyl N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-α-aspartate
CAS No.:224577-22-4
Molecular Formula:C₄₀H₄₄N₄O₇
Molecular Weight:692.812
Hs Code.:

Synonyms:dibenzyl N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-α-aspartate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dibenzyl N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-α-aspartate

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Technology Process of dibenzyl N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-α-aspartate

There total 8 articles about dibenzyl N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-α-aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 224577-14-4
4-<<<(2-methylphenyl)amino>carbonyl>amino>phenylacetate N-hydroxysuccinimide ester

: L-leucyl-L-(α-O-benzylaspartate) benzyl ester hydrochloride

: 224577-22-4
dibenzyl N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-α-aspartate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jm980673g

Reference yield:

: 3392-09-4
Boc-Leu-ONSu

: 224577-22-4
dibenzyl N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-α-aspartate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: 96 percent / 4 M HCl / dioxane / 2 h / Ambient temperature

3: 96 percent / Et₃N / dimethylformamide / 3 h

With hydrogenchloride; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980673g

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 224577-22-4
dibenzyl N-<<4-<<<(2-methylphenyl)amino>carbonyl>amino>phenyl>acetyl>-L-leucyl-L-α-aspartate

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / dimethylformamide / 1 h

2: SOCl₂ / acetonitrile / 0.17 h

3: Et₃N / acetonitrile / 2 h

4: 96 percent / Et₃N / dimethylformamide / 3 h

With thionyl chloride; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm980673g