[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl](2S)-3-[3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]carbamoyl]phenyl]sulfonylthiazolidine-2-carboxylate formate salt

Base Information

Chemical Name:[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl](2S)-3-[3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]carbamoyl]phenyl]sulfonylthiazolidine-2-carboxylate formate salt
CAS No.:1612232-75-3
Molecular Formula:CH₂O₂*C₄₄H₄₄Cl₂F₂N₄O₁₀S₂
Molecular Weight:1007.91
Hs Code.:

[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl](2S)-3-[3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]carbamoyl]phenyl]sulfonylthiazolidine-2-carboxylate formate salt

Synonyms:[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl](2S)-3-[3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]carbamoyl]phenyl]sulfonylthiazolidine-2-carboxylate formate salt

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Chemical Property of [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl](2S)-3-[3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]carbamoyl]phenyl]sulfonylthiazolidine-2-carboxylate formate salt

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Technology Process of [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl](2S)-3-[3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]carbamoyl]phenyl]sulfonylthiazolidine-2-carboxylate formate salt

There total 4 articles about [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl](2S)-3-[3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]carbamoyl]phenyl]sulfonylthiazolidine-2-carboxylate formate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.96%

: 1233329-65-1
(R)-quinuclidin-3-yl 2-amino-2-phenylacetate

: 1415998-22-9
4-((S)-2-(((S)-3-((3-carboxyphenyl)sulfonyl)thiazolidine-2-carbonyl)oxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine-1-oxide

: 1612232-75-3
[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl](2S)-3-[3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]carbamoyl]phenyl]sulfonylthiazolidine-2-carboxylate formate salt

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1612232-82-2
O₃-tert-butyl O₂-[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl](2S)-thiazolidine-2,3-dicarboxylate

: 1612232-75-3
[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl](2S)-3-[3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]carbamoyl]phenyl]sulfonylthiazolidine-2-carboxylate formate salt

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethyl acetate / 0.08 h / 20 °C

2: pyridine / 8 h / 0 - 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1415994-84-1
[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)ethyl](2S)-thiazolidine-2-carboxylate hydrochloride

: 1612232-75-3
[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl](2S)-3-[3-[[2-oxo-1-phenyl-2-[(3R)-quinuclidin-3-yl]oxyethyl]carbamoyl]phenyl]sulfonylthiazolidine-2-carboxylate formate salt

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 8 h / 0 - 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;