1H-Tetrazole-5-carboxylic acid (3-acetyl-5-tert-butyl-2-hydroxy-phenyl)-amide

Base Information

• Chemical Name: 1H-Tetrazole-5-carboxylic acid (3-acetyl-5-tert-butyl-2-hydroxy-phenyl)-amide
• CAS No.: 100245-54-3
• Molecular Formula: C₁₄H₁₇N₅O₃
• Molecular Weight: 303.321

Synonyms:1H-Tetrazole-5-carboxylic acid (3-acetyl-5-tert-butyl-2-hydroxy-phenyl)-amide

Chemical Property of 1H-Tetrazole-5-carboxylic acid (3-acetyl-5-tert-butyl-2-hydroxy-phenyl)-amide

Chemical Property:

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Technology Process of 1H-Tetrazole-5-carboxylic acid (3-acetyl-5-tert-butyl-2-hydroxy-phenyl)-amide

There total 2 articles about 1H-Tetrazole-5-carboxylic acid (3-acetyl-5-tert-butyl-2-hydroxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-(4-Methoxy-benzyl)-1H-tetrazole-5-carboxylic acid (3-acetyl-5-tert-butyl-2-hydroxy-phenyl)-amide (100245-23-6) → 1H-Tetrazole-5-carboxylic acid (3-acetyl-5-tert-butyl-2-hydroxy-phenyl)-amide (100245-54-3)

Guidance literature:

With trifluoroacetic acid; for 0.5h; Heating;

DOI:10.1021/jm00154a019

Reference yield:

1-(3-Amino-5-tert-butyl-2-hydroxy-phenyl)-ethanone (100245-20-3) → 1H-Tetrazole-5-carboxylic acid (3-acetyl-5-tert-butyl-2-hydroxy-phenyl)-amide (100245-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / 1 h / 20 °C

2: 65 percent / CF₃COOH / 0.5 h / Heating

With pyridine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm00154a019

upstream raw materials:

1-(4-Methoxy-benzyl)-1H-tetrazole-5-carboxylic acid (3-acetyl-5-tert-butyl-2-hydroxy-phenyl)-amide

1-(3-Amino-5-tert-butyl-2-hydroxy-phenyl)-ethanone

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