Cyclohexylmethyl-[5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidin-4-yl]-amine

Base Information

Chemical Name:Cyclohexylmethyl-[5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidin-4-yl]-amine
CAS No.:1269625-80-0
Molecular Formula:C₂₃H₂₅FN₄
Molecular Weight:376.477
Hs Code.:

Synonyms:Cyclohexylmethyl-[5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidin-4-yl]-amine

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Chemical Property of Cyclohexylmethyl-[5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidin-4-yl]-amine

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Technology Process of Cyclohexylmethyl-[5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidin-4-yl]-amine

There total 6 articles about Cyclohexylmethyl-[5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidin-4-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1269625-75-3
4-chloro-5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidine

: 3218-02-8
cyclohexylmethylamine

: 1269625-80-0
Cyclohexylmethyl-[5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidin-4-yl]-amine

Guidance literature:: In ethanol;

Reference yield:

: 1643-26-1
3-(2-fluorophenyl)propionic acid

: 1269625-80-0
Cyclohexylmethyl-[5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidin-4-yl]-amine

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / methanol

2: tributyl-amine; trimethylsilyl trifluoromethanesulfonate / titanium tetrachloride / water; toluene

3: sodium methylate / methanol; diethyl ether

4: trichlorophosphate / N,N-dimethyl-aniline

5: ethanol

With thionyl chloride; tributyl-amine; trimethylsilyl trifluoromethanesulfonate; sodium methylate; trichlorophosphate; titanium tetrachloride; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-aniline; toluene;

Reference yield:

: 143654-59-5
methyl 3-(2-fluorophenyl)propanoate

: 1269625-80-0
Cyclohexylmethyl-[5-(2-fluoro-benzyl)-2-pyridin-2-yl-pyrimidin-4-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: tributyl-amine; trimethylsilyl trifluoromethanesulfonate / titanium tetrachloride / water; toluene

2: sodium methylate / methanol; diethyl ether

3: trichlorophosphate / N,N-dimethyl-aniline

4: ethanol

With tributyl-amine; trimethylsilyl trifluoromethanesulfonate; sodium methylate; trichlorophosphate; titanium tetrachloride; In methanol; diethyl ether; ethanol; water; N,N-dimethyl-aniline; toluene;