(+/-)-(3R*,4R*)-3-carbomethoxy-3-(2-methoxy-2-oxoethyl)-4-phenylcyclohex-1-ene

Base Information

• Chemical Name: (+/-)-(3R*,4R*)-3-carbomethoxy-3-(2-methoxy-2-oxoethyl)-4-phenylcyclohex-1-ene
• CAS No.: 113133-34-9
• Molecular Formula: C₁₇H₂₀O₄
• Molecular Weight: 288.343
• Mol file: 113133-34-9.mol

Synonyms:(+/-)-(3R*,4R*)-3-carbomethoxy-3-(2-methoxy-2-oxoethyl)-4-phenylcyclohex-1-ene

Chemical Property of (+/-)-(3R*,4R*)-3-carbomethoxy-3-(2-methoxy-2-oxoethyl)-4-phenylcyclohex-1-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-(3R*,4R*)-3-carbomethoxy-3-(2-methoxy-2-oxoethyl)-4-phenylcyclohex-1-ene

There total 1 articles about (+/-)-(3R*,4R*)-3-carbomethoxy-3-(2-methoxy-2-oxoethyl)-4-phenylcyclohex-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

biphenyl-2-carboxylic acid methyl ester (16605-99-5) + bromoacetic acid methyl ester (96-32-2) → (+/-)-(3R*,4R*)-3-carbomethoxy-3-(2-methoxy-2-oxoethyl)-4-phenylcyclohex-1-ene (113133-34-9)

Guidance literature:

With ammonia; lithium; tert-butyl alcohol; Yield given. Multistep reaction; 1.) -78 deg C, 10 min, 2.) 45 min;

DOI:10.1021/jo00246a012

Reference yield: 86.0%

(+/-)-(3R*,4R*)-3-carbomethoxy-3-(2-methoxy-2-oxoethyl)-4-phenylcyclohex-1-ene (113133-34-9) → (+/-)-(1R*,6R*)-1-carbomethoxy-6-phenyl-2-cyclohexene-1-acetic acid (113133-35-0)

Guidance literature:

With potassium carbonate; In methanol; water; for 4h; Heating;

DOI:10.1021/jo00246a012

Reference yield:

(+/-)-(3R*,4R*)-3-carbomethoxy-3-(2-methoxy-2-oxoethyl)-4-phenylcyclohex-1-ene (113133-34-9) → (+/-)-(1R*,2R*)-1-carbomethoxy-2-phenylcyclohexane-1-acetic acid (113133-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / K₂CO₃ / methanol; H₂O / 4 h / Heating

2: 96 percent / H₂ / Pd/C / ethyl acetate; methanol / 15 h

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; water; ethyl acetate;

DOI:10.1021/jo00246a012

upstream raw materials:

biphenyl-2-carboxylic acid methyl ester

bromoacetic acid methyl ester

Downstream raw materials:

(+/-)-(1R*,6R*)-1-carbomethoxy-6-phenyl-2-cyclohexene-1-acetic acid

(+/-)-(1R*,2R*)-1-carbomethoxy-2-phenylcyclohexane-1-acetic acid