4-amino-6-((2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methoxy)-5-pyrimidinecarbonitrile

Base Information

Chemical Name:4-amino-6-((2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methoxy)-5-pyrimidinecarbonitrile
CAS No.:1312605-53-0
Molecular Formula:C₂₀H₁₃FN₆O
Molecular Weight:372.361
Hs Code.:

Synonyms:4-amino-6-((2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methoxy)-5-pyrimidinecarbonitrile

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Chemical Property of 4-amino-6-((2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methoxy)-5-pyrimidinecarbonitrile

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Technology Process of 4-amino-6-((2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methoxy)-5-pyrimidinecarbonitrile

There total 9 articles about 4-amino-6-((2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methoxy)-5-pyrimidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312605-86-9
(2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methanol

: 60025-09-4
4-amino-6-chloropyrimidine-5-carbonitrile

: 1312605-53-0
4-amino-6-((2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methoxy)-5-pyrimidinecarbonitrile

Guidance literature:: (2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h;

4-amino-6-chloropyrimidine-5-carbonitrile; In N,N-dimethyl-formamide; mineral oil; at 20 - 50 ℃;

Reference yield:

: 36052-27-4
methyl 3-aminopicolinate

: 1312605-53-0
4-amino-6-((2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methoxy)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: 0.75 h / Reflux

2.1: sodium ethanolate / ethanol / 1 h / 20 °C

3.1: trichlorophosphate / 48 h / 130 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 6 h / Reflux

5.1: diisobutylaluminium hydride / toluene / 0 - 20 °C

5.2: 0.17 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

6.2: 20 - 50 °C

With sodium ethanolate; sodium hydride; diisobutylaluminium hydride; sodium carbonate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1312605-84-7
ethyl 2,4-dichloro-1,5-naphthyridine-3-carboxylate

: 1312605-53-0
4-amino-6-((2-(3-fluorophenyl)-1,5-naphthyridin-3-yl)methoxy)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 6 h / Reflux

2.1: diisobutylaluminium hydride / toluene / 0 - 20 °C

2.2: 0.17 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

3.2: 20 - 50 °C

With sodium hydride; diisobutylaluminium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;