(3R)-3,7,7-trimethyl-3-phenylpyrrolo[2,1-c][1,4]oxazine-1,4,6,8-tetraone

Base Information

Chemical Name:(3R)-3,7,7-trimethyl-3-phenylpyrrolo[2,1-c][1,4]oxazine-1,4,6,8-tetraone
CAS No.:342797-12-0
Molecular Formula:C₁₆H₁₅NO₅
Molecular Weight:301.299
Hs Code.:

Synonyms:(3R)-3,7,7-trimethyl-3-phenylpyrrolo[2,1-c][1,4]oxazine-1,4,6,8-tetraone

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Chemical Property of (3R)-3,7,7-trimethyl-3-phenylpyrrolo[2,1-c][1,4]oxazine-1,4,6,8-tetraone

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Technology Process of (3R)-3,7,7-trimethyl-3-phenylpyrrolo[2,1-c][1,4]oxazine-1,4,6,8-tetraone

There total 10 articles about (3R)-3,7,7-trimethyl-3-phenylpyrrolo[2,1-c][1,4]oxazine-1,4,6,8-tetraone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 342797-11-9
ethyl (2'R)-2,2-dimethyl-3-(2'-methyl-3',6'-dioxo-2'-phenylmorpholin-4'-yl)-3-oxopropionate

: 342797-12-0
(3R)-3,7,7-trimethyl-3-phenylpyrrolo[2,1-c][1,4]oxazine-1,4,6,8-tetraone

Guidance literature:: With chloro-trimethyl-silane; titanium tetrachloride; triethylamine; In dichloromethane; at -78 - -41 ℃; for 5h;
DOI:10.1021/ol015757p

Reference yield:

: 5471-77-2
3-ethoxy-2,2-dimethyl-3-oxopropanoic acid

: 342797-12-0
(3R)-3,7,7-trimethyl-3-phenylpyrrolo[2,1-c][1,4]oxazine-1,4,6,8-tetraone

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride / benzene; dimethylformamide / 1.5 h / 20 °C

2: 1.89 g / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

3: 87 percent / TiCl₄; Et₃N; TMSCl / CH₂Cl₂ / 5 h / -78 - -41 °C

With dmap; chloro-trimethyl-silane; oxalyl dichloride; titanium tetrachloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; benzene; 3: Dieckmann cyclization;
DOI:10.1021/ol015757p

Reference yield:

: 64244-87-7
2-chlorocarbonyl-2-methylpropanoic acid ethyl ester

: 342797-12-0
(3R)-3,7,7-trimethyl-3-phenylpyrrolo[2,1-c][1,4]oxazine-1,4,6,8-tetraone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.89 g / Et₃N; DMAP / CH₂Cl₂ / 0 - 20 °C

2: 87 percent / TiCl₄; Et₃N; TMSCl / CH₂Cl₂ / 5 h / -78 - -41 °C

With dmap; chloro-trimethyl-silane; titanium tetrachloride; triethylamine; In dichloromethane; 2: Dieckmann cyclization;
DOI:10.1021/ol015757p