2'-O-acetyl-3'-azidomethyl-5'-[(tert-butyldiphenylsilyloxy)methyl]-3',5'-dideoxyadenosine

Base Information

Chemical Name:2'-O-acetyl-3'-azidomethyl-5'-[(tert-butyldiphenylsilyloxy)methyl]-3',5'-dideoxyadenosine
CAS No.:906795-47-9
Molecular Formula:C₃₀H₃₆N₈O₄Si
Molecular Weight:600.753
Hs Code.:

Synonyms:2'-O-acetyl-3'-azidomethyl-5'-[(tert-butyldiphenylsilyloxy)methyl]-3',5'-dideoxyadenosine

Suppliers and Price of 2'-O-acetyl-3'-azidomethyl-5'-[(tert-butyldiphenylsilyloxy)methyl]-3',5'-dideoxyadenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2'-O-acetyl-3'-azidomethyl-5'-[(tert-butyldiphenylsilyloxy)methyl]-3',5'-dideoxyadenosine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2'-O-acetyl-3'-azidomethyl-5'-[(tert-butyldiphenylsilyloxy)methyl]-3',5'-dideoxyadenosine

There total 1 articles about 2'-O-acetyl-3'-azidomethyl-5'-[(tert-butyldiphenylsilyloxy)methyl]-3',5'-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 674790-06-8
1,2-di-O-acetyl-3-azidomethyl-5-[(tert-butyldiphenylsiloxy)methyl]-3,5-dideoxyribofuranose

: 906795-47-9
2'-O-acetyl-3'-azidomethyl-5'-[(tert-butyldiphenylsilyloxy)methyl]-3',5'-dideoxyadenosine

Guidance literature:: With tin(IV) chloride; In acetonitrile; at 20 ℃; for 0.05h;
DOI:10.1021/jo060457c

Reference yield:

: 906795-47-9
2'-O-acetyl-3'-azidomethyl-5'-[(tert-butyldiphenylsilyloxy)methyl]-3',5'-dideoxyadenosine

: [(2R,3S,4R,5R)-3-Azidomethyl-5-(6-benzoylamino-purin-9-yl)-4-hydroxy-tetrahydro-furan-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / NaOH / H₂O; methanol / 72 h / 20 °C

2.1: trimethylsilyl chloride; pyridine / CH₂Cl₂ / 1 h / 20 °C

2.2: CH₂Cl₂ / 4 h / 0 °C

2.3: 89 percent / methanol / CH₂Cl₂ / 20 °C

3.1: sodium chlorite; TEMPO; tetrabutylammonium chloride / phosphate buffer; sodium hypochlorite / H₂O; acetonitrile / 0.08 h / 20 °C / pH 7

With pyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydroxide; sodium chlorite; chloro-trimethyl-silane; tetrabutyl-ammonium chloride; sodium hypochlorite; phosphate buffer; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo060457c

Reference yield:

: 906795-47-9
2'-O-acetyl-3'-azidomethyl-5'-[(tert-butyldiphenylsilyloxy)methyl]-3',5'-dideoxyadenosine

: 3'-azidomethyl-6-N-benzoyl-2'-O-tert-butyldimethylsilyl-5'-carboxy-3',5'-dideoxyadenosine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / NaOH / H₂O; methanol / 72 h / 20 °C

2.1: trimethylsilyl chloride; pyridine / CH₂Cl₂ / 1 h / 20 °C

2.2: CH₂Cl₂ / 4 h / 0 °C

2.3: 89 percent / methanol / CH₂Cl₂ / 20 °C

3.1: sodium chlorite; TEMPO; tetrabutylammonium chloride / phosphate buffer; sodium hypochlorite / H₂O; acetonitrile / 0.08 h / 20 °C / pH 7

4.1: 21 mg / 2,6-lutidine / CH₂Cl₂ / 48 h / 20 °C

With pyridine; 2,6-dimethylpyridine; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydroxide; sodium chlorite; chloro-trimethyl-silane; tetrabutyl-ammonium chloride; sodium hypochlorite; phosphate buffer; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo060457c