Technology Process of C35H47N3O6
There total 8 articles about C35H47N3O6 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU;
In
dichloromethane;
at 0 - 20 ℃;
for 72h;
Inert atmosphere;
DOI:10.1016/j.bmcl.2011.10.045
- Guidance literature:
-
Multi-step reaction with 4 steps
1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 5 h / 0 - 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / Inert atmosphere
3: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C
4: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 72 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU;
In
1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.10.045
- Guidance literature:
-
Multi-step reaction with 6 steps
1: dmap; diisopropyl-carbodiimide / dichloromethane; water / 30 h / 0 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / Inert atmosphere
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 5 h / 0 - 20 °C / Inert atmosphere
4: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / Inert atmosphere
5: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C
6: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 72 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; dmap; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; diisopropyl-carbodiimide;
In
1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.10.045