Fenticonazole nitrate

Base Information

• Chemical Name: Fenticonazole nitrate
• CAS No.: 73151-29-8
• Molecular Formula: C24H20Cl2N2OS^.HNO3
• Molecular Weight: 518.41
• Hs Code.: 2942000000
• European Community (EC) Number: 277-302-6
• UNII: 8V4JGC8YRF
• DSSTox Substance ID: DTXSID30993890
• Wikidata: Q27157007
• NCI Thesaurus Code: C81508
• ChEMBL ID: CHEMBL2107703
• Mol file: 73151-29-8.mol

Synonyms:1-(2,4-dichloro-beta-((p-(phenylthio)benzyl)oxy)phenethyl)imidazole;Fenizolan;fenticonazole;fenticonazole mononitate;Laurimic;Lomexin;Micofulvin;Rec 15-1476;Terlomexin

Chemical Property of Fenticonazole nitrate

Chemical Property:

• Vapor Pressure: 1.93E-15mmHg at 25°C
• Melting Point: 135-137oC
• Refractive Index: 1.632
• Boiling Point: 637.2oC at 760 mmHg
• PKA: 6.54(at 25℃)
• Flash Point: 339.2oC
• PSA: 118.40000
• Density: 1.26g/cm3
• LogP: 7.47470
• Storage Temp.: Refrigerator
• Solubility.: Practically insoluble in water, freely soluble in dimethylformamide and in methanol, sparingly soluble in anhydrous ethanol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 8
• Exact Mass: 517.0629827
• Heavy Atom Count: 34
• Complexity: 524

Purity/Quality:

99% ^*data from raw suppliers

Fenticonazole Nitrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)SC2=CC=C(C=C2)COC(CN3C=CN=C3)C4=C(C=C(C=C4)Cl)Cl.[N+](=O)(O)[O-]
• Description: Fenticonazole nitrate is an antifungal imidazole derivative reported to be more effective than other imidazole antifungals such as miconazole, clotrimazole and econazole. In addition to its potent, broad-spectrum fungicidal activity, fenticonazole is also active against some Gram-positive bacteria. Fenticonazole is an imidazole with antimicrobial activity. It is active against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii with MIC values ranging from 0.12 to 32 μg/ml. It is also active against clinical isolates of bacteria, including B. fragilis, associated with bacterial vaginosis (MICs = ≤0.03-16 μg/ml), as well as bacteria, including S. aureus and S. epidermidis, associated with skin infections with MIC values ranging from 0.03 μg/ml or less to greater than 16 μg/ml. Fenticonazole inhibits fungal growth in a guinea pig model of experimental M. canis dermatomycosis (ED50 = 0.5%, applied topically).
• Uses: Broad spectrum antimycotic; also active as antibacterial. Antifungal (topical).
• Therapeutic Function: Antifungal