11-benzyl-5-difluoromethoxy-11-aza-tricyclo[7.3.1.02,7]trideca-2⁽⁷⁾,3,5-triene

Base Information

Chemical Name:11-benzyl-5-difluoromethoxy-11-aza-tricyclo[7.3.1.02,7]trideca-2⁽⁷⁾,3,5-triene
CAS No.:248275-97-0
Molecular Formula:C₂₀H₂₁F₂NO
Molecular Weight:329.39
Hs Code.:

11-benzyl-5-difluoromethoxy-11-aza-tricyclo[7.3.1.02,7]trideca-2<sup>(7)</sup>,3,5-triene

Synonyms:11-benzyl-5-difluoromethoxy-11-aza-tricyclo[7.3.1.02,7]trideca-2⁽⁷⁾,3,5-triene

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Chemical Property of 11-benzyl-5-difluoromethoxy-11-aza-tricyclo[7.3.1.02,7]trideca-2⁽⁷⁾,3,5-triene

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Technology Process of 11-benzyl-5-difluoromethoxy-11-aza-tricyclo[7.3.1.02,7]trideca-2⁽⁷⁾,3,5-triene

There total 8 articles about 11-benzyl-5-difluoromethoxy-11-aza-tricyclo[7.3.1.02,7]trideca-2⁽⁷⁾,3,5-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 248275-92-5
11-benzyl-11-aza-tricyclo[7.3.1.02,7]trideca-2⁽⁷⁾,3,5-trien-5-ol

: 248275-97-0
11-benzyl-5-difluoromethoxy-11-aza-tricyclo[7.3.1.02,7]trideca-2⁽⁷⁾,3,5-triene

Guidance literature:: With potassium hydroxide; In 1,4-dioxane; water;

Reference yield:

: cyclopent-3-enyl-(5-difluoromethoxy-2-hydroxy-phenyl)-methanone

: 248275-97-0
11-benzyl-5-difluoromethoxy-11-aza-tricyclo[7.3.1.02,7]trideca-2⁽⁷⁾,3,5-triene

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂

2: Ph₃P(CH₂)3PPh₃; KOAc; Et₃N / Pd(OAc)2 / dimethylformamide / 110 °C

3: 93 percent / N₂H₄; KOH; ethanediol / Heating

4: aq. OsO₄; (CH₂)5NCH₃O / acetone

5: aq. NaIO₄ / 1,2-dichloro-ethane

6: NaBH(OAc)3 / 1,2-dichloro-ethane

With pyridine; potassium hydroxide; sodium periodate; osmium(VIII) oxide; (CH₂)5NCH₃O; Ph₃P(CH₂)3PPh₃; potassium acetate; sodium tris(acetoxy)borohydride; ethylene glycol; triethylamine; hydrazine; palladium diacetate; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; 2: Heck reaction / 3: Wolff-Kishner reduction;
DOI:10.1016/j.bmcl.2005.04.036

Reference yield:

: 861220-75-9
trifluoro-methanesulfonic acid 2-(cyclopent-3-enecarbonyl)-4-difluoromethoxy-phenyl ester

: 248275-97-0
11-benzyl-5-difluoromethoxy-11-aza-tricyclo[7.3.1.02,7]trideca-2⁽⁷⁾,3,5-triene

Guidance literature:: Multi-step reaction with 5 steps

1: Ph₃P(CH₂)3PPh₃; KOAc; Et₃N / Pd(OAc)2 / dimethylformamide / 110 °C

2: 93 percent / N₂H₄; KOH; ethanediol / Heating

3: aq. OsO₄; (CH₂)5NCH₃O / acetone

4: aq. NaIO₄ / 1,2-dichloro-ethane

5: NaBH(OAc)3 / 1,2-dichloro-ethane

With potassium hydroxide; sodium periodate; osmium(VIII) oxide; (CH₂)5NCH₃O; Ph₃P(CH₂)3PPh₃; potassium acetate; sodium tris(acetoxy)borohydride; ethylene glycol; triethylamine; hydrazine; palladium diacetate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; 1: Heck reaction / 2: Wolff-Kishner reduction;
DOI:10.1016/j.bmcl.2005.04.036