N-tert-butoxycarbonyl-L-prolyl-L-prolyl-O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester

Base Information

• Chemical Name: N-tert-butoxycarbonyl-L-prolyl-L-prolyl-O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester
• CAS No.: 1158995-39-1
• Molecular Formula: C₄₀H₆₁N₇O₁₁
• Molecular Weight: 815.965
• Mol file: 1158995-39-1.mol

Synonyms:N-tert-butoxycarbonyl-L-prolyl-L-prolyl-O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester

Chemical Property of N-tert-butoxycarbonyl-L-prolyl-L-prolyl-O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonyl-L-prolyl-L-prolyl-O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester

There total 4 articles about N-tert-butoxycarbonyl-L-prolyl-L-prolyl-O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester trifluoroacetate (1158995-41-5) + N-tert-butoxycarbonyl-L-prolyl-L-proline (15401-08-8) → N-tert-butoxycarbonyl-L-prolyl-L-prolyl-O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester (1158995-39-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 23h;

DOI:10.1039/b823559g

Reference yield:

ethylene dichloride hydrochloride + 3-methyl-N-(3-methylbutyl)-1-butanamine (544-00-3) + α,α-dimethylglycyl-L-valine methyl ester trifluoroacetate (1158995-00-6) + O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester trifluoroacetate (1158995-41-5) + N-tert-butoxycarbonyl-L-prolyl-L-proline (15401-08-8) → N-tert-butoxycarbonyl-L-prolyl-L-prolyl-O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester (1158995-39-1)

Guidance literature:

In dichloromethane;

Reference yield:

N-tert-butoxycarbonyl-L-prolyl-L-proline methyl ester (52386-41-1) → N-tert-butoxycarbonyl-L-prolyl-L-prolyl-O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester (1158995-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water

2: dichloromethane

With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

O-benzyl-L-seryl-L-valyl-L-valyl-glycyl-glycine methyl ester trifluoroacetate

N-tert-butoxycarbonyl-L-prolyl-L-proline

3-methyl-N-(3-methylbutyl)-1-butanamine

α,α-dimethylglycyl-L-valine methyl ester trifluoroacetate