methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate
CAS No.:1383000-51-8
Molecular Formula:C₂₈H₃₅F₄N₃O₄Si
Molecular Weight:581.683
Hs Code.:

methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

Synonyms:methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

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Chemical Property of methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

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Technology Process of methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

There total 1 articles about methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383000-29-0
methyl 2,2-dimethyl-3-{[4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}propanoate

: 1383000-50-7
2-(4-bromo-2-fluorophenyl)-4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole

: 1383000-51-8
methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 60 ℃; for 5h; Inert atmosphere;

Reference yield:

: 1383000-51-8
methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

: 1383000-52-9
3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoic acid

Guidance literature:: methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

: 1383000-51-8
methyl 3-[(5-{3-fluoro-4-[4-(trifluoromethyl)-1-{[2-(trimethyl-silyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoate

: 1383000-53-0
3-[(5-{3-fluoro-4-[5-(trifluoromethyl)-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C

2: water; trifluoroacetic acid / 10 h / 20 °C

With water; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol;