3-(2-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide

Base Information

Chemical Name:3-(2-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide
CAS No.:1332302-08-5
Molecular Formula:C₂₁H₂₀FN₅O₂
Molecular Weight:393.421
Hs Code.:

Synonyms:3-(2-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide

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Chemical Property of 3-(2-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide

Chemical Property:

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Technology Process of 3-(2-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide

There total 2 articles about 3-(2-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63843-78-7
3-(4-fluorophenoxy)-azetidine hydrochloride

: 1332302-09-6
3-(2-chloropyrimidin-4-ylamino)-N-methylbenzamide

: 1332302-08-5
3-(2-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 84 ℃; for 48h; Sealed tube;

Reference yield:

: 25900-61-2
3-amino-N-methylbenzamide

: 1332302-08-5
3-(2-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-4-ylamino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 117 h / 20 - 80 °C / Sealed tube

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 48 h / 84 °C / Sealed tube

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol;