ethyl 2-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)acetate

Base Information

Chemical Name:ethyl 2-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)acetate
CAS No.:1384111-08-3
Molecular Formula:C₁₆H₁₅F₃N₂O₃S
Molecular Weight:372.368
Hs Code.:

Synonyms:ethyl 2-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)acetate

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Chemical Property of ethyl 2-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)acetate

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Technology Process of ethyl 2-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)acetate

There total 5 articles about ethyl 2-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 623-33-6
glycine ethyl ester hydrochloride

: 144059-86-9
4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid

: 1384111-08-3
ethyl 2-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)acetate

Guidance literature:: 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

glycine ethyl ester hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 17h; Inert atmosphere;
DOI:10.1002/anie.201410341

Reference yield:

: 175277-03-9
4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester

: 1384111-08-3
ethyl 2-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / methanol; water / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / Inert atmosphere

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-13-12865

Reference yield:

: 72505-21-6
4-trifluoromethylbenzthioamide

: 1384111-08-3
ethyl 2-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxamido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 2 h / Reflux; Inert atmosphere

2: lithium hydroxide monohydrate / methanol; water / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / Inert atmosphere

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-13-12865