1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester monohydrochloride

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Chemical Name:1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester monohydrochloride
CAS No.:123486-03-3
Molecular Formula:C₂₃H₂₃F₃N₂O₃S*ClH
Molecular Weight:500.969
Hs Code.:

1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester monohydrochloride

Synonyms:1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester monohydrochloride

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Chemical Property of 1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester monohydrochloride

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Technology Process of 1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester monohydrochloride

There total 1 articles about 1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 114957-75-4
2-[[2-(trifluoromethyl)phenyl]methylene]-3-oxobutanoic acid,ethyl ester

: 25985-08-4
2-(4-methoxybenzyl)isothiourea hydrochloride

: 123486-03-3
1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester monohydrochloride

Guidance literature:: With sodium acetate; In N,N-dimethyl-formamide; at 70 ℃; for 4h;
DOI:10.1021/jo00286a020

Reference yield:

: 123486-03-3
1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester monohydrochloride

: 106-94-5
propyl bromide

: 123486-04-4
1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-1-propyl-5-pyrimidinecarboxylic acid ethyl ester

: 123486-09-9
1,6-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-4-methyl-6-<2-(trifluoromethyl)phenyl>-1-propyl-5-pyrimidinecarboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃;
DOI:10.1021/jo00286a020

Reference yield:

: 123486-03-3
1,4-dihydro-2-<<(4-methoxyphenyl)methyl>thio>-6-methyl-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester monohydrochloride

: 123485-95-0
1,2,3,4-tetrahydro-6-methyl-1-propyl-2-thioxo-4-<2-(trifluoromethyl)phenyl>-5-pyrimidinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 0.88 g / potassium carbonate / dimethylformamide / 70 °C

2: 0.41 g / trifluoroacetic acid, ethanethiol / CH₂Cl₂ / Ambient temperature

With potassium carbonate; trifluoroacetic acid; ethanethiol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00286a020