3-(trifluoromethyl)phenyl (3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate trifluoroacetate

Base Information

Chemical Name:3-(trifluoromethyl)phenyl (3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate trifluoroacetate
CAS No.:1610719-18-0
Molecular Formula:C₂HF₃O₂*C₂₄H₂₄F₃N₇O₃
Molecular Weight:629.519
Hs Code.:

Synonyms:3-(trifluoromethyl)phenyl (3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate trifluoroacetate

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Chemical Property of 3-(trifluoromethyl)phenyl (3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate trifluoroacetate

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Technology Process of 3-(trifluoromethyl)phenyl (3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate trifluoroacetate

There total 3 articles about 3-(trifluoromethyl)phenyl (3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610714-42-5
8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-6-[(3S)pyrrolidin-3-yloxy]-9H-purine

: 76-05-1
trifluoroacetic acid

: 95668-29-4
3-(trifluoromethyl)phenyl carbonochloridate

: 1610719-18-0
3-(trifluoromethyl)phenyl (3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate trifluoroacetate

Guidance literature:: 8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-6-[(3S)pyrrolidin-3-yloxy]-9H-purine; 3-(trifluoromethyl)phenyl carbonochloridate; With triethylamine; In N,N-dimethyl-formamide; at 15 - 25 ℃; Inert atmosphere;

trifluoroacetic acid;

Reference yield:

: 1365607-39-1
6-chloro-8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purine

: 1610719-18-0
3-(trifluoromethyl)phenyl (3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 15 - 25 °C / Inert atmosphere

With sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1610714-59-4
tert-butyl (3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate

: 1610719-18-0
3-(trifluoromethyl)phenyl (3S)-3-{[8-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-yl]oxy}pyrrolidine-1-carboxylate trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide / 15 - 25 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;