4-tert.-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-benzene sulfonamide

Base Information

Chemical Name:4-tert.-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-benzene sulfonamide
CAS No.:167403-78-3
Molecular Formula:C₂₅H₂₉ClN₄O₅S
Molecular Weight:533.048
Hs Code.:

Synonyms:4-tert.-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-benzene sulfonamide

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Chemical Property of 4-tert.-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-benzene sulfonamide

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Technology Process of 4-tert.-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-benzene sulfonamide

There total 6 articles about 4-tert.-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-benzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 110-91-8,99108-56-2
morpholine

: 4-t-butyl-N-[2,6-dichloro-5-(2-methoxyphenoxy)-4-pyrimidinyl]benzenesulfonamide

: 167403-78-3
4-tert.-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-benzene sulfonamide

Guidance literature:: In dimethyl sulfoxide;

Reference yield:

: 4-tert.-butylbenzene sulfonamide potassium salt

: 167403-77-2
4,6-dichloro-5-(2-methoxy-phenoxy)-2-(morpholin-4-yl)pyrimidine

: 167403-78-3
4-tert.-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-benzene sulfonamide

Guidance literature:: With acetic acid; In diethyl ether; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 20730-58-9
2-(2-Methoxyphenoxy)propanedioic acid diethyl ester

: 167403-78-3
4-tert.-butyl-N-[6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl]-benzene sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: NaOMe / methanol / 18 h / 20 °C

2: POCl₃; PhNMe₂ / 120 °C

3: dimethylsulfoxide / 20 - 60 °C

With sodium methylate; N,N-dimethyl-aniline; trichlorophosphate; In methanol; dimethyl sulfoxide;
DOI:10.1016/S0960-894X(02)01084-3