(S)-methyl 2-((benzyloxycarbonyl)(methyl)amino)-3-(1-(5-(2-(tertbutoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenyl)-1H-imidazol-4-yl)propanoate

Base Information

Chemical Name:(S)-methyl 2-((benzyloxycarbonyl)(methyl)amino)-3-(1-(5-(2-(tertbutoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenyl)-1H-imidazol-4-yl)propanoate
CAS No.:1192262-31-9
Molecular Formula:C₃₁H₄₀N₄O₈
Molecular Weight:596.681
Hs Code.:

Synonyms:(S)-methyl 2-((benzyloxycarbonyl)(methyl)amino)-3-(1-(5-(2-(tertbutoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenyl)-1H-imidazol-4-yl)propanoate

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Chemical Property of (S)-methyl 2-((benzyloxycarbonyl)(methyl)amino)-3-(1-(5-(2-(tertbutoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenyl)-1H-imidazol-4-yl)propanoate

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Technology Process of (S)-methyl 2-((benzyloxycarbonyl)(methyl)amino)-3-(1-(5-(2-(tertbutoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenyl)-1H-imidazol-4-yl)propanoate

There total 2 articles about (S)-methyl 2-((benzyloxycarbonyl)(methyl)amino)-3-(1-(5-(2-(tertbutoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenyl)-1H-imidazol-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1192262-33-1
5-(2-(tert-butoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenylboronic acid

: 133999-80-1
Cbz-MeHis-OMe

: 1192262-31-9
(S)-methyl 2-((benzyloxycarbonyl)(methyl)amino)-3-(1-(5-(2-(tertbutoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenyl)-1H-imidazol-4-yl)propanoate

Guidance literature:: With [Cu(OH)TMEDA]2Cl₂; In dichloromethane; for 36h; regioselective reaction;
DOI:10.1021/jo901744y

Reference yield:

: 1192262-23-9
tert-butyl 3-iodo-4-(methoxymethoxy)phenethylcarbamate

: 133999-80-1
Cbz-MeHis-OMe

: 1192262-31-9
(S)-methyl 2-((benzyloxycarbonyl)(methyl)amino)-3-(1-(5-(2-(tertbutoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenyl)-1H-imidazol-4-yl)propanoate

Guidance literature:: tert-butyl 3-iodo-4-(methoxymethoxy)phenethylcarbamate; With bis-triphenylphosphine-palladium(II) chloride; potassium acetate; bis(tri-n-butyltin); In 1-methyl-pyrrolidin-2-one; at 20 ℃;

With lead(IV) tetraacetate; mercury(II) trifluoroacetate; sodium hydroxide; In chloroform; water; at 30 ℃; Darkness; Inert atmosphere;

Cbz-MeHis-OMe; With copper diacetate; In dichloromethane; at 20 ℃; for 4h; regioselective reaction;
DOI:10.1021/jo901744y

Reference yield:

: 1038864-01-5
Boc-Pro-Ala-Val-OH

: 1192262-31-9
(S)-methyl 2-((benzyloxycarbonyl)(methyl)amino)-3-(1-(5-(2-(tertbutoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenyl)-1H-imidazol-4-yl)propanoate

: C₄₂H₅₇N₇O₁₀

: 1192262-34-2
C₄₄H₆₁N₇O₁₁

Guidance literature:: (S)-methyl 2-((benzyloxycarbonyl)(methyl)amino)-3-(1-(5-(2-(tertbutoxycarbonylamino)ethyl)-2-(methoxymethoxy)phenyl)-1H-imidazol-4-yl)propanoate; With trifluoroacetic acid; for 0.0333333h;

Boc-Pro-Ala-Val-OH; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jo901744y