8-{1-methyl-5-[3-(4-trifluoromethoxyphenyl)prop-2-ynyloxy]-1H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

Base Information

Chemical Name:8-{1-methyl-5-[3-(4-trifluoromethoxyphenyl)prop-2-ynyloxy]-1H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione
CAS No.:1188541-37-8
Molecular Formula:C₂₅H₂₅F₃N₆O₄
Molecular Weight:530.507
Hs Code.:

Synonyms:8-{1-methyl-5-[3-(4-trifluoromethoxyphenyl)prop-2-ynyloxy]-1H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

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Chemical Property of 8-{1-methyl-5-[3-(4-trifluoromethoxyphenyl)prop-2-ynyloxy]-1H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

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Technology Process of 8-{1-methyl-5-[3-(4-trifluoromethoxyphenyl)prop-2-ynyloxy]-1H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

There total 8 articles about 8-{1-methyl-5-[3-(4-trifluoromethoxyphenyl)prop-2-ynyloxy]-1H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₉F₃N₆O₅Si

: 1188541-37-8
8-{1-methyl-5-[3-(4-trifluoromethoxyphenyl)prop-2-ynyloxy]-1H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

Guidance literature:: With hydrogenchloride; In ethanol; at 80 ℃; for 2h;
DOI:10.1016/j.ejmech.2017.04.014

Reference yield:

: 1239775-52-0
5-(benzyloxy)-1-methyl-1H-pyrazole-3-carboxylic acid

: 1188541-37-8
8-{1-methyl-5-[3-(4-trifluoromethoxyphenyl)prop-2-ynyloxy]-1H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol / 20 °C

2: sodium hydroxide / methanol / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4: hydrogen; palladium 10% on activated carbon / dichloromethane; methanol / 20 °C

5: potassium carbonate / acetone / 5 h / Reflux

6: hydrogenchloride / ethanol / 2 h / 80 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.ejmech.2017.04.014

Reference yield:

: C₂₈H₄₀N₆O₄Si

: 1188541-37-8
8-{1-methyl-5-[3-(4-trifluoromethoxyphenyl)prop-2-ynyloxy]-1H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / dichloromethane; methanol / 20 °C

2: potassium carbonate / acetone / 5 h / Reflux

3: hydrogenchloride / ethanol / 2 h / 80 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; ethanol; dichloromethane; acetone;
DOI:10.1016/j.ejmech.2017.04.014