dimethyl(cyclohexyl)silylacetic acid

Base Information

• Chemical Name: dimethyl(cyclohexyl)silylacetic acid
• CAS No.: 1269600-98-7
• Molecular Formula: C₁₀H₂₀O₂Si
• Molecular Weight: 200.353
• Mol file: 1269600-98-7.mol

Synonyms:dimethyl(cyclohexyl)silylacetic acid

Chemical Property of dimethyl(cyclohexyl)silylacetic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of dimethyl(cyclohexyl)silylacetic acid

There total 3 articles about dimethyl(cyclohexyl)silylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

trimethylsilyl acetate (2754-27-0) + chloro-cyclohexyl-dimethylsilane (71864-47-6) → dimethyl(cyclohexyl)silylacetic acid (1269600-98-7)

Guidance literature:

trimethylsilyl acetate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2.25h; Inert atmosphere;

chloro-cyclohexyl-dimethylsilane; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; pH=1;

DOI:10.1016/j.tet.2010.12.020

Reference yield:

chloro-cyclohexyl-dimethylsilane (71864-47-6) → dimethyl(cyclohexyl)silylacetic acid (1269600-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / 2 h / -78 °C

1.2: 2 h / -78 °C

2.1: Acidic conditions

With lithium diisopropyl amide;

DOI:10.1021/jo200254z

Reference yield:

C13H28O2Si2 → dimethyl(cyclohexyl)silylacetic acid (1269600-98-7)

Guidance literature:

Acidic conditions;

DOI:10.1021/jo200254z

upstream raw materials:

trimethylsilyl acetate

chloro-cyclohexyl-dimethylsilane

Downstream raw materials:

1,2-bis[dimethyl(cyclohexyl)silyl]ethane