(S)-(-)-4-(t-butyldiphenylsilyloxy)-3-propyl-5,6-dihydrobenzo-7(4H)-furanone

Base Information

Chemical Name:(S)-(-)-4-(t-butyldiphenylsilyloxy)-3-propyl-5,6-dihydrobenzo-7(4H)-furanone
CAS No.:1454573-59-1
Molecular Formula:C₂₇H₃₂O₃Si
Molecular Weight:432.635
Hs Code.:

Synonyms:(S)-(-)-4-(t-butyldiphenylsilyloxy)-3-propyl-5,6-dihydrobenzo-7(4H)-furanone

Suppliers and Price of (S)-(-)-4-(t-butyldiphenylsilyloxy)-3-propyl-5,6-dihydrobenzo-7(4H)-furanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-(-)-4-(t-butyldiphenylsilyloxy)-3-propyl-5,6-dihydrobenzo-7(4H)-furanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-(-)-4-(t-butyldiphenylsilyloxy)-3-propyl-5,6-dihydrobenzo-7(4H)-furanone

There total 7 articles about (S)-(-)-4-(t-butyldiphenylsilyloxy)-3-propyl-5,6-dihydrobenzo-7(4H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1454573-58-0
(S)-(-)-4-(t-butyldiphenylsilyloxy)-4-(4-propylfuran-3-yl)butyric acid

: 1454573-59-1
(S)-(-)-4-(t-butyldiphenylsilyloxy)-3-propyl-5,6-dihydrobenzo-7(4H)-furanone

Guidance literature:: With trifluoroacetic anhydride; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol402345x

Reference yield:

: 86650-50-2
1-pentynylzinc chloride

: 1454573-59-1
(S)-(-)-4-(t-butyldiphenylsilyloxy)-3-propyl-5,6-dihydrobenzo-7(4H)-furanone

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran; hexane / -78 - 20 °C / Inert atmosphere

2: (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II) / dichloromethane; isopropyl alcohol / 15 h / 20 °C / Inert atmosphere

3: dmap; 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

4: hydroquinone / 20 h / 260 - 270 °C / Sealed tube; Inert atmosphere; Darkness

5: water; lithium hydroxide / methanol / 1 h / 65 °C

6: trifluoroacetic anhydride / dichloromethane / 2 h / 0 °C / Inert atmosphere

With 1H-imidazole; dmap; (1S,2S)-(+)-N-tosyl-1,2-diphenylethane-1,2-diamine[η6-1-isopropyl-4-methylbenzene]-ruthenium(II); water; hydroquinone; trifluoroacetic anhydride; lithium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; 6: |Friedel-Crafts Acylation;
DOI:10.1021/ol402345x

Reference yield:

: 1454573-53-5
(S)-(-)-ethyl 4-(t-butyldiphenylsilyloxy)-non-5-ynoate

: 1454573-59-1
(S)-(-)-4-(t-butyldiphenylsilyloxy)-3-propyl-5,6-dihydrobenzo-7(4H)-furanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydroquinone / 20 h / 260 - 270 °C / Sealed tube; Inert atmosphere; Darkness

2: water; lithium hydroxide / methanol / 1 h / 65 °C

3: trifluoroacetic anhydride / dichloromethane / 2 h / 0 °C / Inert atmosphere

With water; hydroquinone; trifluoroacetic anhydride; lithium hydroxide; In methanol; dichloromethane; 3: |Friedel-Crafts Acylation;
DOI:10.1021/ol402345x