11-<(Benzyloxy)carbonyl>-1'-ethyl-5,17-dimethoxy-4,18-dimethyl-8,11,14-triaza-2,6:16,20-dimethenospiro-9,13-dione

Base Information

• Chemical Name: 11-<(Benzyloxy)carbonyl>-1'-ethyl-5,17-dimethoxy-4,18-dimethyl-8,11,14-triaza-2,6:16,20-dimethenospiro-9,13-dione
• CAS No.: 123597-24-0
• Molecular Formula: C₃₇H₄₆N₄O₆
• Molecular Weight: 642.795

Synonyms:11-<(Benzyloxy)carbonyl>-1'-ethyl-5,17-dimethoxy-4,18-dimethyl-8,11,14-triaza-2,6:16,20-dimethenospiro-9,13-dione

Chemical Property of 11-<(Benzyloxy)carbonyl>-1'-ethyl-5,17-dimethoxy-4,18-dimethyl-8,11,14-triaza-2,6:16,20-dimethenospiro-9,13-dione

Chemical Property:

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Technology Process of 11-<(Benzyloxy)carbonyl>-1'-ethyl-5,17-dimethoxy-4,18-dimethyl-8,11,14-triaza-2,6:16,20-dimethenospiro-9,13-dione

There total 5 articles about 11-<(Benzyloxy)carbonyl>-1'-ethyl-5,17-dimethoxy-4,18-dimethyl-8,11,14-triaza-2,6:16,20-dimethenospiro-9,13-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

(benzyloxycarbonyl)bis<<(pentafluorophenoxy)carbonyl>methyl>amine (105400-47-3) + 1-Ethyl-4,4-bis(3-(aminomethyl)-4-methoxy-5-methylphenyl)piperidine (123597-23-9) → 11-<(Benzyloxy)carbonyl>-1'-ethyl-5,17-dimethoxy-4,18-dimethyl-8,11,14-triaza-2,6:16,20-dimethenospiro-9,13-dione (123597-24-0)

Guidance literature:

In chloroform; at 20 ℃; for 3h;

DOI:10.1021/ja00204a017

Reference yield:

1-acetyl-4,4-bis(3-bromo-4-hydroxy-5-methylphenyl)piperidine (108787-21-9) → 11-<(Benzyloxy)carbonyl>-1'-ethyl-5,17-dimethoxy-4,18-dimethyl-8,11,14-triaza-2,6:16,20-dimethenospiro-9,13-dione (123597-24-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 68 percent / 5percent NaOH / 1.) 40 deg C, 30 min, 2.) reflux, 1.5 h

2: 72 percent / dimethylformamide / 15 h / Heating

3: 1.) BH₃*THF, 2.) conc. H₂SO₄ / 1.) THF, reflux, 24 h, 2.) EtOH, reflux, 30 min

4: 33 percent / CHCl₃ / 3 h / 20 °C

With sodium hydroxide; borane-THF; sulfuric acid; In chloroform; N,N-dimethyl-formamide;

DOI:10.1021/ja00204a017

Reference yield:

1-Acetyl-4,4-bis(3-bromo-4-methoxy-5-methylphenyl)piperidine (123597-21-7) → 11-<(Benzyloxy)carbonyl>-1'-ethyl-5,17-dimethoxy-4,18-dimethyl-8,11,14-triaza-2,6:16,20-dimethenospiro-9,13-dione (123597-24-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / dimethylformamide / 15 h / Heating

2: 1.) BH₃*THF, 2.) conc. H₂SO₄ / 1.) THF, reflux, 24 h, 2.) EtOH, reflux, 30 min

3: 33 percent / CHCl₃ / 3 h / 20 °C

With borane-THF; sulfuric acid; In chloroform; N,N-dimethyl-formamide;

DOI:10.1021/ja00204a017

upstream raw materials:

(benzyloxycarbonyl)bis<<(pentafluorophenoxy)carbonyl>methyl>amine

1-Ethyl-4,4-bis(3-(aminomethyl)-4-methoxy-5-methylphenyl)piperidine

1-acetyl-4,4-bis(3-bromo-4-hydroxy-5-methylphenyl)piperidine

1-Acetyl-4,4-bis(3-bromo-4-methoxy-5-methylphenyl)piperidine

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