N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide

Base Information

• Chemical Name: N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide
• CAS No.: 1022973-35-8
• Molecular Formula: C₁₂H₁₃Cl₂F₃N₄O
• Molecular Weight: 357.163

Synonyms:N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide

Chemical Property of N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide

Chemical Property:

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Technology Process of N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide

There total 2 articles about N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2R)-N-(2,5-dichloro-pyrimidin-4-yl)cyclohexane-1,2-diamine (1245830-90-3) + trifluoroacetic anhydride (407-25-0) → N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide (1022973-35-8) + C14H12Cl2F6N4O2

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.25h;

DOI:10.1016/j.bmcl.2011.05.040

Reference yield:

(1R,2R)-1,2-diaminocyclohexane (20439-47-8) → N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide (1022973-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.08 h / 0 °C

2: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

With triethylamine; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2011.05.040

Reference yield:

3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine (1022955-97-0) + N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide (1022973-35-8) → N-((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-2,2,2-trifluoroacetamide (1022973-42-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl methyl ether; at 120 ℃;

DOI:10.1016/j.bmcl.2011.05.040

upstream raw materials:

(1R,2R)-N-(2,5-dichloro-pyrimidin-4-yl)cyclohexane-1,2-diamine

trifluoroacetic anhydride

(1R,2R)-1,2-diaminocyclohexane

Downstream raw materials:

N-((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)-2,2,2-trifluoroacetamide

N-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}-2,2,2-trifluoroacetamide

N⁽⁴⁾-((1R,2R)-2-aminocyclohexyl)-5-chloro-N⁽²⁾-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]pyrimidine-2,4-diamine

ethanesulfonic acid ((1R,2R)-2-{5-chloro-2-[3-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]pyrimidin-4-ylamino}cyclohexyl)amide

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