N-(2-cyclohexylethyl)-6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-amine

Base Information

Chemical Name:N-(2-cyclohexylethyl)-6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-amine
CAS No.:1187836-72-1
Molecular Formula:C₂₄H₃₁N₇OS
Molecular Weight:465.622
Hs Code.:

Synonyms:N-(2-cyclohexylethyl)-6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-amine

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Chemical Property of N-(2-cyclohexylethyl)-6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-amine

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Technology Process of N-(2-cyclohexylethyl)-6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-amine

There total 12 articles about N-(2-cyclohexylethyl)-6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187837-10-0
tert-butyl (2-cyclohexylethyl)(6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-yl)carbamate

: 1187836-72-1
N-(2-cyclohexylethyl)-6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-amine

Guidance literature:: tert-butyl (2-cyclohexylethyl)(6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-yl)carbamate; With trifluoroacetic acid; In dichloromethane; at 0 - 45 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 19798-81-3,1184170-10-2
2-Amino-6-bromopyridine

: 1187836-72-1
N-(2-cyclohexylethyl)-6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dmap / dichloromethane / 5 h / 0 °C

2.1: n-butyllithium; methyllithium / tetrahydrofuran

2.2: 1.5 h / -78 - 20 °C

3.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.08 h / 0 °C

4.2: 4 h / 20 °C

5.1: triethylamine / acetonitrile / 0 - 20 °C

6.1: caesium carbonate / potassium iodide / acetonitrile / 18 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 0 - 45 °C

With sodium tetrahydroborate; n-butyllithium; potassium tert-butylate; methyllithium; caesium carbonate; triethylamine; trifluoroacetic acid; dmap; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 616196-32-8
N-methoxy-N-methyl-3-(methylsulfanyl)benzamide

: 1187836-72-1
N-(2-cyclohexylethyl)-6-{[({[3-(methylsulfanyl)phenyl](1-methyl-1H-tetrazol-5-yl)methylene}amino)oxy]methyl}pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0 °C

1.2: 5 - 20 °C

2.1: pyridine; hydroxylamine hydrochloride / 5 h / 70 °C

3.1: caesium carbonate / potassium iodide / acetonitrile / 18 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 0 - 45 °C

With pyridine; hydroxylamine hydrochloride; isopropylmagnesium chloride; caesium carbonate; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; dichloromethane; acetonitrile;