2-((9H-purin-6-ylamino)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Base Information

Chemical Name:2-((9H-purin-6-ylamino)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one
CAS No.:1300585-47-0
Molecular Formula:C₂₁H₁₃F₂N₅O₂
Molecular Weight:405.363
Hs Code.:

Synonyms:2-((9H-purin-6-ylamino)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

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Chemical Property of 2-((9H-purin-6-ylamino)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Chemical Property:

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Technology Process of 2-((9H-purin-6-ylamino)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

There total 5 articles about 2-((9H-purin-6-ylamino)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1300585-50-5
C₁₆H₁₁F₂NO₂

: 87-42-3
6-chloropurine

: 1300585-47-0
2-((9H-purin-6-ylamino)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tert-butyl alcohol; for 24h; Reflux;

Reference yield:

: 331-25-9
(3-fluorophenyl)acetic acid

: 1300585-47-0
2-((9H-purin-6-ylamino)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

1.2: 12 h / 0 - 20 °C

2.1: triethylamine; HATU / dichloromethane / 12 h / 20 °C

3.1: trifluoroacetic acid / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 24 h / Reflux

With oxalyl dichloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane; tert-butyl alcohol;

Reference yield:

: 459-60-9
1-fluoro-4-methoxybenzene

: 1300585-47-0
2-((9H-purin-6-ylamino)methyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

1.2: 12 h / 0 - 20 °C

2.1: triethylamine; HATU / dichloromethane / 12 h / 20 °C

3.1: trifluoroacetic acid / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 24 h / Reflux

With oxalyl dichloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane; tert-butyl alcohol;