5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride

Base Information

Chemical Name:5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride
CAS No.:81580-12-3
Molecular Formula:C₂₀H₂₅N₃O₄*ClH
Molecular Weight:407.897
Hs Code.:

Synonyms:5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride

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Chemical Property of 5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride

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Technology Process of 5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride

There total 4 articles about 5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 81580-11-2
4-{3-[2-(3-Carbamoyl-4-hydroxy-phenyl)-2-hydroxy-ethylamino]-butyl}-benzoic acid methyl ester

: 81580-12-3
5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride

Guidance literature:: With ammonium hydroxide; for 192h; Ambient temperature;
DOI:10.1021/jm00348a013

Reference yield:

: 30566-92-8
5-(N,N-dibenzylamino)acetylsalicylamide

: 81580-12-3
5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / H₂, AcOH / 10percent PdO/C, 10percent Pt/C / methanol / 760 Torr / Ambient temperature

2: 41 percent / NH₄OH / 192 h / Ambient temperature

With ammonium hydroxide; hydrogen; acetic acid; platinum on activated charcoal; palladium oxide on charcoal; In methanol;
DOI:10.1021/jm00348a013

Reference yield:

: 73866-23-6
5-(2-bromoacetyl)-2-hydroxybenzamide

: 81580-12-3
5-{2-[3-(4-Carbamoyl-phenyl)-1-methyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-benzamide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / butan-2-one / 0.67 h / Heating

2: 90 percent / H₂, AcOH / 10percent PdO/C, 10percent Pt/C / methanol / 760 Torr / Ambient temperature

3: 41 percent / NH₄OH / 192 h / Ambient temperature

With ammonium hydroxide; hydrogen; acetic acid; platinum on activated charcoal; palladium oxide on charcoal; In methanol; butanone;
DOI:10.1021/jm00348a013