4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfonyl)ethyl]-1-naphthalenecarboxamide

Base Information

Chemical Name:4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfonyl)ethyl]-1-naphthalenecarboxamide
CAS No.:1093861-20-1
Molecular Formula:C₂₄H₁₉Cl₂F₃N₂O₄S
Molecular Weight:559.393
Hs Code.:

Synonyms:4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfonyl)ethyl]-1-naphthalenecarboxamide

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Chemical Property of 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfonyl)ethyl]-1-naphthalenecarboxamide

Chemical Property:

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Technology Process of 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfonyl)ethyl]-1-naphthalenecarboxamide

There total 6 articles about 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfonyl)ethyl]-1-naphthalenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092708-24-1
4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfinyl)ethyl]-1-naphthalenecarboxamide

: 1093861-20-1
4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfonyl)ethyl]-1-naphthalenecarboxamide

Guidance literature:: With dihydrogen peroxide; In water; acetic acid;

Reference yield:

: C₂₁H₁₁Cl₃F₃NO₂

: 1093861-20-1
4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfonyl)ethyl]-1-naphthalenecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2.5 h / -78 - -70 °C

3: dihydrogen peroxide; acetic acid / water / 4 h / 60 °C

With dihydrogen peroxide; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water;

Reference yield:

: 943847-20-9
methyl 4-[(hydroxyimino)methyl]-1-naphthalenecarboxylate

: 1093861-20-1
4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-(methylsulfonyl)ethyl]-1-naphthalenecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 20 °C

1.2: 2 h / 20 °C

2.1: lithium hydroxide monohydrate / water; methanol; tetrahydrofuran / 20 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1.5 h / 20 °C

4.1: triethylamine / dichloromethane / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2.5 h / -78 - -70 °C

6.1: dihydrogen peroxide; acetic acid / water / 4 h / 60 °C

With N-chloro-succinimide; oxalyl dichloride; lithium hydroxide monohydrate; dihydrogen peroxide; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;