Technology Process of N4-p-bromobenzoyl-2',3'-O-isopropylidene-O2,5'-cyclocytidine
There total 3 articles about N4-p-bromobenzoyl-2',3'-O-isopropylidene-O2,5'-cyclocytidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: perchloric acid / 1.5 h / 20 °C
1.2: 0.25 h
2.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
With
perchloric acid; di-isopropyl azodicarboxylate; triphenylphosphine;
In
dichloromethane;
2.1: Mitsunobu reaction;
DOI:10.1021/ol301769j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine; chloro-trimethyl-silane / 2 h / 20 °C
1.2: 2 h
1.3: 0.5 h / 0 °C
2.1: perchloric acid / 1.5 h / 20 °C
2.2: 0.25 h
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
With
pyridine; chloro-trimethyl-silane; perchloric acid; di-isopropyl azodicarboxylate; triphenylphosphine;
In
dichloromethane;
3.1: Mitsunobu reaction;
DOI:10.1021/ol301769j
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine; chloro-trimethyl-silane / 2 h / 20 °C
1.2: 2 h
1.3: 0.5 h / 0 °C
2.1: perchloric acid / 1.5 h / 20 °C
2.2: 0.25 h
3.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
With
pyridine; chloro-trimethyl-silane; perchloric acid; di-isopropyl azodicarboxylate; triphenylphosphine;
In
dichloromethane;
3.1: Mitsunobu reaction;
DOI:10.1021/ol301769j
