2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid tert-butyl ester

Base Information

• Chemical Name: 2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid tert-butyl ester
• CAS No.: 1350753-84-2
• Molecular Formula: C₁₆H₂₃NO₅
• Molecular Weight: 309.362
• Mol file: 1350753-84-2.mol

Synonyms:2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid tert-butyl ester

Chemical Property of 2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid tert-butyl ester

There total 1 articles about 2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.1%

bromoacetic acid tert-butyl ester (5292-43-3) + benzyl 2-hydroxyethylcarbamate (77987-49-6) → 2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid tert-butyl ester (1350753-84-2)

Guidance literature:

benzyl 2-hydroxyethylcarbamate; With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; at 20 ℃; for 2.5h; Large scale;

bromoacetic acid tert-butyl ester; In dichloromethane; at 20 - 30 ℃; Large scale;

Reference yield: 97.0%

2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid tert-butyl ester (1350753-84-2) → tert-butyl 2-(2-aminoethoxy)acetate (1155811-37-2)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 5h; Autoclave; Large scale;

Reference yield:

2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid tert-butyl ester (1350753-84-2) → 2-[2-[3-(benzyloxycarbonyl)-2-thioureido]ethoxy]acetic acid tert-butyl ester (1350753-92-2)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C / 15001.5 Torr

2: triethylamine / dichloromethane / 2 h / 2 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;

DOI:10.1007/s00706-011-0660-x

upstream raw materials:

bromoacetic acid tert-butyl ester

benzyl 2-hydroxyethylcarbamate

Downstream raw materials:

2-[2-[3-(benzyloxycarbonyl)-2-thioureido]ethoxy]acetic acid tert-butyl ester

C₂₅H₃₉N₃O₈

tert-butyl 2-(2-aminoethoxy)acetate