N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)propiolamide

Base Information

Chemical Name:N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)propiolamide
CAS No.:1428444-19-2
Molecular Formula:C₁₉H₁₆N₈O
Molecular Weight:372.389
Hs Code.:

Synonyms:N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)propiolamide

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Chemical Property of N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)propiolamide

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Technology Process of N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)propiolamide

There total 5 articles about N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)propiolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23002-51-9
6-chloro-1H-pyrazolo[3,4-d]pyrimidine

: 1428444-19-2
N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)propiolamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 20 h / 20 °C

2: hydrogenchloride / isopropyl alcohol; water / 18 h / 90 °C

3: hydrogenchloride; palladium on activated charcoal; hydrogen / water; methanol / 2 h

4: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1428444-29-4
1-(3-aminobenzyl)-N-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

: 471-25-0
Propiolic acid

: 1428444-19-2
N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)propiolamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 1428444-27-2
6-chloro-1-(3-nitrobenzyl)-1H-pyrazolo[3,4-d]pyrimidine

: 1428444-19-2
N-(3-((6-((1-methyl-1H-pyrazol-4-yl)amino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)phenyl)propiolamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / isopropyl alcohol; water / 18 h / 90 °C

2: hydrogenchloride; palladium on activated charcoal; hydrogen / water; methanol / 2 h

3: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With hydrogenchloride; palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;