2-Ethyl-2-[(3S,4R)-3-(3-fluoro-phenyl)-4-formyl-pyrrolidin-1-ylmethyl]-butyric acid benzyl ester

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Chemical Name:2-Ethyl-2-[(3S,4R)-3-(3-fluoro-phenyl)-4-formyl-pyrrolidin-1-ylmethyl]-butyric acid benzyl ester
CAS No.:442876-64-4
Molecular Formula:C₂₅H₃₀FNO₃
Molecular Weight:411.517
Hs Code.:

Synonyms:2-Ethyl-2-[(3S,4R)-3-(3-fluoro-phenyl)-4-formyl-pyrrolidin-1-ylmethyl]-butyric acid benzyl ester

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Chemical Property of 2-Ethyl-2-[(3S,4R)-3-(3-fluoro-phenyl)-4-formyl-pyrrolidin-1-ylmethyl]-butyric acid benzyl ester

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Technology Process of 2-Ethyl-2-[(3S,4R)-3-(3-fluoro-phenyl)-4-formyl-pyrrolidin-1-ylmethyl]-butyric acid benzyl ester

There total 1 articles about 2-Ethyl-2-[(3S,4R)-3-(3-fluoro-phenyl)-4-formyl-pyrrolidin-1-ylmethyl]-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-Ethyl-2-[(3S,4R)-3-(3-fluoro-phenyl)-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-butyric acid benzyl ester

: 442876-64-4
2-Ethyl-2-[(3S,4R)-3-(3-fluoro-phenyl)-4-formyl-pyrrolidin-1-ylmethyl]-butyric acid benzyl ester

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃;
DOI:10.1021/ol034707c

Reference yield:

: 442876-64-4
2-Ethyl-2-[(3S,4R)-3-(3-fluoro-phenyl)-4-formyl-pyrrolidin-1-ylmethyl]-butyric acid benzyl ester

: 2-{[(3S,4S)-3-[(4-{3-Benzyl-1-ethyl-1H-pyrazol-5-yl}piperidin-1-yl)methyl]-4-(3-fluorophenyl)pyrrolidin-1-yl]methyl}-2-ethylbutyric Acid

Guidance literature:: Multi-step reaction with 2 steps

1: NaB(OAc)3H / CH₂Cl₂

2: H₂ / Pd/C / methanol

With hydrogen; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/ol034707c